Effects of Zinc Coadministration on Lead Toxicities in Rats

DOI Web Site Web Site 被引用文献1件 参考文献26件
  • PIAO Fengyuan
    Department of Hygiene, Dalian Medical University
  • CHENG Fanyin
    Department of Health Administration, Dalian Medical University
  • CHEN Haibo
    Central laboratory, Dalian Medical University
  • LI Gang
    Liaoning Institute of Occupational Health
  • SUN Xiance
    Department of Hygiene, Dalian Medical University
  • LIU Shuang
    Department of Hygiene, Dalian Medical University
  • YAMAUCHI Toru
    Department of Public Health, Graduate School of Medicine, Mie University
  • YOKOYAMA Kazuhito
    Department of Public Health, Graduate School of Medicine, Mie University

この論文をさがす

抄録

In order to investigate the effects of Zn on Pb toxicities. Proportion of abnormal sperm, percentage of micronucleated polychromatic erythrocyte (MPCE), serum thyroid hormones (T3, T4) and cortisol were measured. Rats received intraperitoneal injection of 25 mg/kg Pb acetate, 4 mg/kg Zn acetate, both Pb acetate and Zn acetate, or normal saline as controls, once every two days, 7 times in total. No significant differences in whole blood Pb were detected between groups received Pb alone or both Pb and Zn. On the contrary, the concentration of whole blood Zn in the group given Zn alone was significantly higher than that in the group that received both Pb and Zn. In the groups given Pb alone or both Pb and Zn, proportion of abnormal sperm, frequency of MPCE and serum cortisol were significantly higher than those in controls, whereas serum T3 and T4 were significantly lower than in controls. In the group given both Pb and Zn, T4 was decreased most obviously among the four groups. While the proportion of abnormal sperm was less in the group given both Pb and Zn than in the group given Pb alone. These findings suggest that Zn coadministration might alleviate toxic effects of Pb on the male reproductive system, whereas it could enhance the toxicity on thyroid function. Zn did not affect the toxicities of Pb on cytogenetic systems as indicated by MPCE percentage, and on serum cortisol levels under the dose of the present study. Our results suggested the double-edged effects of Zn on Pb toxicities in different organs. Therefore, the effects of Zn on Pb toxicities should be evaluated systematically.<br>

収録刊行物

被引用文献 (1)*注記

もっと見る

参考文献 (26)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ