Urinay 8-oxo-7,8-dihydro-2'-deoxyguanosine and Biopyrrins Levels among Construction Workers with Asbestos Exposure History
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- YOSHIDA Rie
- National Institute of Industrial Health
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- OGAWA Yasutaka
- National Institute of Industrial Health
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- SHIOJI Izuru
- Shino-Test Corporation
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- YU Xiaozhong
- National Institute of Industrial Health
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- SHIBATA Eiji
- Department of Medical Technology, Nagoya University School of Health Sciences
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- MORI Ippei
- National Institute of Industrial Health
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- KUBOTA Hitoshi
- National Institute of Industrial Health
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- KISHIDA Akiko
- Kitasato University
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- HISANAGA Naomi
- National Institute of Industrial Health
書誌事項
- タイトル別名
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- Urinary 8-oxo-7,8-dihydro-2'-deoxyguanosine and Biopyrrins Levels among Construction Workers with Asbestos Exposure History.
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抄録
It has been suggested that oxidative stress is associated with the cancers caused by asbestos. Since construction workers are sometimes exposed to low levels of asbestos, we investigated whether oxidative stress was elevated in construction workers who had been exposed to low levels of asbestos. The subjects were 48 Japanese construction workers. The defined asbestos-exposed group consisted of subjects who had the history of suspected exposure to asbestos and were diagnosed to have irregular opacities or pleural plaques. We measured the amount of 8-oxo-7, 8-dihydro-2'-deoxyguanosine (8-oxodG) and biopyyrins in the urine of the subjects. The results showed that 8-oxodG and biopyyrins levels in the defined asbestos-exposed group were higher, although they were not statistically significant, than those in the control group. In addition, the urinary 8-oxodG levels tended to correlate positively with the duration of suspected exposure to asbestos. These results suggest that even lowlevel asbestos exposure may induce oxidative stress and that the resulting's the oxidative stress might be related to lung cancer in construction workers.
収録刊行物
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- Industrial health
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Industrial health 39 (2), 186-188, 2001
独立行政法人 労働者健康安全機構 労働安全衛生総合研究所
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詳細情報 詳細情報について
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- CRID
- 1390001204280397184
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- NII論文ID
- 130003550996
- 40005265735
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- NII書誌ID
- AA00672955
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- COI
- 1:CAS:528:DC%2BD3MXjvVCntr8%3D
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- ISSN
- 18808026
- 00198366
- http://id.crossref.org/issn/00178853
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- NDL書誌ID
- 5786270
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- PubMed
- 11341550
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可