Lung Lesions Induced by Intratracheal Instillation of Vanadium Pentoxide Powder in Rats.
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- TOYA Tadao
- National Institute of Industrial Health
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- FUKUDA Kazuo
- National Institute of Industrial Health
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- TAKAYA Mitsutoshi
- National Institute of Industrial Health
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- ARITO Heihachiro
- National Institute of Industrial Health
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To clarify acute toxicity and histopathological changes in the lung after exposure to V2O5 powder, rats (SD, male, n=66) were observed for 4 weeks after an intratracheal administration of V2O5 powder (geometric mean diameter 0.31 μm, geomertic standard deviation σg=2.19) at three doses (0.88, 3.0, 13.0 mg/kg body weight). The histopathological lung lesions were developed dosedependently, and characterized by exudative inflammation, injury of alveolar macrophages, and swelling and mucous degeneration in the broncho-bronchiolar epithelia. Growth rate of the V2O5 powder-instilled rat was also retarded dose-dependently. The V2O5 powder used was composed of not coagulated but well dispersed particles consisting of vanadium pentoxide of more than 99.8% (w/w) with vanadium tetraoxide of less than 0.2%. The V2O5 powder was found to be 8 times more soluble in an artificial biological fluid “Gamble's solution” than in a pure water. From the present findings as well as those from the related literature, it was inferred that the histopathological lesions induced by the intratracheally instilled V2O5 powder are caused not only by the V2O5 particles per se but also by vanadium ions dissolved from the particles into the lung fluid.
収録刊行物
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- Industrial health
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Industrial health 39 (1), 8-15, 2001
独立行政法人 労働者健康安全機構 労働安全衛生総合研究所
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詳細情報 詳細情報について
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- CRID
- 1390001204280986368
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- NII論文ID
- 130003550972
- 40005265710
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- NII書誌ID
- AA00672955
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- ISSN
- 18808026
- 00198366
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- NDL書誌ID
- 5994812
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- PubMed
- 11212290
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可