Taurine inhibits 2,5-hexanedione-induced oxidative stress and mitochondria-dependent apoptosis in PC12 cells
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- LI Shuangyue
- Department of Occupational and Environmental Health, Dalian Medical University, China
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- GUAN Huai
- Department of Obstetrics and Gynecology, No. 210 Hospital of PLA, China
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- QIAN Zhiqiang
- Department of Occupational and Environmental Health, Dalian Medical University, China
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- SUN Yijie
- Department of Occupational and Environmental Health, Dalian Medical University, China
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- GAO Chenxue
- Department of Occupational and Environmental Health, Dalian Medical University, China
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- LI Guixin
- Clinical laboratory, the First Affiliated Hospital of Dalian Medical University, China
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- YANG Yi
- Department of neurosurgery, General Hospital of Beijing Military Command, China
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- PIAO Fengyuan
- Department of Occupational and Environmental Health, Dalian Medical University, China
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- HU Shuhai
- College of Stomatology, Dalian Medical University, China
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説明
<p>2,5-hexanedione (HD) is the ultimate neurotoxic metabolite of hexane, causing the progression of nerve diseases in human. It was reported that HD induced apoptosis and oxidative stress. Taurine has been shown to be a potent antioxidant. In the present study, we investigated the protection of taurine against HD-induced apoptosis in PC12 cells and the underlying mechanism. Our results showed the decreased viability and increased apoptosis in HD-exposed PC12 cells. HD also induced the disturbance of Bax and Bcl-2 expression, the loss of MMP, the release of mitochondrial cytochrome c and caspase-3 activation in PC12 cells. Moreover, HD resulted in an increase in reactive oxygen species (ROS) level and a decline in the activities of superoxidedismutase and catalase in PC12 cells. However, taurine pretreatment ameliorated the increased apoptosis and the alterations in key regulators of mitochondria-dependent pathway in PC12 exposed to HD. The increased ROS level and the decreased activities of the antioxidant enzymes in HD group were attenuated by taurine. These results indicate that pretreatment of taurine may, at least partly, prevent HD-induced apoptosis via inhibiting mitochondria-dependent pathway. It is also suggested that the potential of taurine against HD-induced apoptosis may benefit from its anti-oxidative property.</p>
収録刊行物
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- Industrial health
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Industrial health 55 (2), 108-118, 2017
独立行政法人 労働者健康安全機構 労働安全衛生総合研究所
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詳細情報 詳細情報について
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- CRID
- 1390001204281511936
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- NII論文ID
- 130005558267
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- NII書誌ID
- AA00672955
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- ISSN
- 18808026
- 00198366
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- NDL書誌ID
- 028102361
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- PubMed
- 27840369
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 使用不可