Involvement of .GAMMA.-Aminobutyric Acid (GABA) B Receptors in the Hypotensive Effect of Systemically Administered GABA in Spontaneously Hypertensive Rats.
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- Kimura Masayuki
- Yakult Central Institute for Microbiological Research
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- Hayakawa Kazuhito
- Yakult Central Institute for Microbiological Research
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- Sansawa Hiroshi
- Yakult Central Institute for Microbiological Research
Bibliographic Information
- Other Title
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- Involvement of γ-Aminobutyric Acid (GABA) B Receptors in the Hypotensive Effect of Systemically Administered GABA in Spontaneously Hypertensive Rats
- Involvement of ガンマ Aminobutyric Acid GABA B Receptors in the Hypotensive Effect of Systemically Administered GABA in Spontaneously Hypertensive Rats
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Abstract
We investigated the effects of intraduodenally (i.d.) administered γ-aminobutyric acid (GABA) on blood pressure (BP) in anesthetized spontaneously hypertensive rats (SHR) and the mechanism underlying this effect, especially the type of GABA receptor involved in the depressive effect of this amino acid. GABA (0.3 to 300 mg/kg, i.d.) caused a dose-related decrease in the BP of 9.20 ± 3.96 to 35.0 ± 5.34 mmHg (mean ± S.E.M.) that lasted for 30 to 50 min. The minimum effective i.d. dose of GABA was 0.3 to 1.0 mg/kg. Results pertaining to the mechanism underlying the GABA-induced effects on BP were as follows: a) GABA did not alter the BP-related effects of exogenous noradrenaline and acetylcholine; b) pretreatment with hexamethonium decreased the GABA-induced fall in BP, and GABA tended to reduce the pressor response associated with injection of dimethyl phenylpiperazinium; and c) pretreatment with 2-hydroxysaclofen markedly reduced the GABA-induced drop in BP, whereas pretreatment with bicuculline did not. In conclusion, in SHR, low-dose (0.3 to 1.0 mg/kg, i.d.) GABA had a hypotensive effect, which may result from attenuation of sympathetic transmission through the activation of GABAB receptors at presynaptic or ganglionic sites.
Journal
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- The Japanese Journal of Pharmacology
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The Japanese Journal of Pharmacology 89 (4), 388-394, 2002
The Japanese Pharmacological Society
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Keywords
Details 詳細情報について
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- CRID
- 1390001204284528768
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- NII Article ID
- 130000078462
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- NII Book ID
- AA00691188
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- COI
- 1:STN:280:DC%2BD38vnt1ejsA%3D%3D
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- ISSN
- 13473506
- 00215198
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- NDL BIB ID
- 6276769
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- PubMed
- 12233817
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed