Effects of L-765,314, a Selective and Potent α1B-Adrenoceptor Antagonist, on Periarterial Nerve Electrical Stimulation-Induced Double-Peaked Constrictor Responses in Isolated Dog Splenic Arteries

Yang Xiao-Ping, Chiba Shigetoshi

doi:10.1254/jjp.89.429

Effects of L-765,314, a Selective and Potent α1B-Adrenoceptor Antagonist, on Periarterial Nerve Electrical Stimulation-Induced Double-Peaked Constrictor Responses in Isolated Dog Splenic Arteries

DOI Web Site Web Site Web Site PubMed 被引用文献1件参考文献26件

Yang Xiao-Ping

Department of Pharmacology, Shinshu University School of Medicine
Chiba Shigetoshi

Department of Pharmacology, Shinshu University School of Medicine

書誌事項

タイトル別名

Effects of L-765,314, a Selective and Potent .ALPHA.1B-Adrenoceptor Antagonist, on Periarterial Nerve Electrical Stimulation-Induced Double-Peaked Constrictor Responses in Isolated Dog Splenic Arteries.
Effects of L 765 314 a Selective and Potent アルファ 1B Adrenoceptor Antagonist on Periarterial Nerve Electrical Stimulation Induced Double Peaked Constrictor Responses in Isolated Dog Splenic Arteries

この論文をさがす

抄録

The periarterial nerve electrical stimulation (PNS) at a frequency of 1 or 4 Hz (30-s trains of pulses) readily caused a double peaked vasoconstriction in the canine splenic artery. The treatment with 1 μM L-765,314, a selective and potent α_1B-adrenoceptor antagonist, markedly inhibited the second peaked constriction, whereas it did not modify the vasoconstrictor responses to exogenous noradrenaline (0.03 – 1 nmol) and A61603 (1 – 30 pmol), a selective α_1A-agonist. A large dose of 10 μM L-765,314 significantly blocked exogenous noradrenaline- and A61603-induced responses. It is concluded that PNS-induced responses are mediated via the postjunctional α_1B-adrenoceptor subtype.