Immunopharmacological Studies of the Aqueous Extract of Cinnamomum cassia(CCAq)-2-Effect of CCAq on Experimental Glomerulonephritis
-
- NAGAI Hiroichi
- Department of Pharmacology, Gifu College of Pharmacy
-
- SHIMAZAWA Tsukasa
- International Academy of Paramedical Technology
-
- TAKIZAWA Tamotsu
- Department of Pharmacology, Gifu College of Pharmacy
-
- KODA Akihide
- Department of Pharmacology, Gifu College of Pharmacy
-
- YAGI Akira
- Department of Pharmacognosy, Faculty of Kyushu University
-
- NISHIOKA Itsuo
- Department of Pharmacognosy, Faculty of Kyushu University
書誌事項
- タイトル別名
-
- Immunopharmacological studies of the aqueous extract of Cinnamomum Cassia (CCAq). II. Effect of CCAq on experimental glomerulonephritis.
- Immunopharmacological Studies of the Aq
- Immunopharmacological studies of the aqueous extract of C/n-namomum cassia (CCAq). II. Effect of CCAq on experimental glomerulonephritis
この論文をさがす
説明
Effect of the aqueous extract of Cinnamomum Cassia (CCAq) on experimental glomerulonephritis was studied and compared with that of cobra venom factor (CoVF). In rat nephrotoxic serum (NTS) nephritis, CCAq clearly inhibited the excretion of protein into the urine and the increase of peripheral leucocyte counts. The histological score in CCAq administered animals was significantly lower than that in control animals. However, CCAq did not inhibit or lower the serum complement level. Contrary to CCAq, hypocomplementation was observed by the administration of CoVF, and the excretion of protein into urine was inhibited in a high dose group. In immune complex (IC) and autologous IC nephritis in rats, CCAq clearly inhibited the excretion of protein into urine and the elevation of blood urea nitrogen (BUN). The administration of CoVF caused hypocomplementation, but little inhibition of the excretion of urinary protein was observed in both types of immune complex nephritis. The histological score was slightly inhibited by a low dose of CCAq and a high dose of CoVF. In the experiment employing NZB/NZW F1 mice, the proteinurea, the elevation of BUN level, and the production of antibodies were clearly inhibited by the administration of CCAq. Similar inhibition was observed by CoVF at a high dose. However, the histological changes of the kidney in NZB/NZW F1 mice were not prevented by the administration of CCAq or CoVF.
収録刊行物
-
- Jpn.J.Pharmacol.
-
Jpn.J.Pharmacol. 32 (5), 823-831, 1982
公益社団法人 日本薬理学会
- Tweet
キーワード
詳細情報 詳細情報について
-
- CRID
- 1390001204284749952
-
- NII論文ID
- 130000835388
-
- NII書誌ID
- AA00691188
-
- COI
- 1:STN:280:BiyD1cnltFc%3D
-
- ISSN
- 13473506
- 00215198
-
- NDL書誌ID
- 2500840
-
- PubMed
- 7176217
-
- 本文言語コード
- en
-
- 資料種別
- journal article
-
- データソース種別
-
- JaLC
- NDLサーチ
- Crossref
- PubMed
- CiNii Articles
- OpenAIRE
-
- 抄録ライセンスフラグ
- 使用不可