Monitorning of Radical Scavenging Activity of Peroral Administration of the Kampo Medicine Sho-saiko-to in Rats

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  • Monitoring of Radical Scavenging Activity of Peroral Administration of the Kampo Medicine Sho-saiko-to in Rats.
  • Monitoring of radical scavenging ability of peroral administration of Kampo medicine Sho-saiko-to in rats

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The Kampo medicine Sho-saiko-to scavenged superoxide anion radicals (O2-), hydroxyl radicals (·OH) and 1, 1-diphenyl-2-picrylhydrazyl (DPPH) radicals in a dose-dependent fashion. We attempted to investigate the transition of free radical scavenging activity in plasma after oral administration of Sho-saiko-to in rats. From the response-time profile, kinetic parameters including values for Ka (absorption rate constant), Tmax (peak concentration time), T1/2 (half life) and MRT (mean residence time) of radical scavenging activity in plasma could be calculated for the O2-, ·OH and DPPH radicals. These parameters calculated from the dynamics of antioxidation are considered a very meaningful procedure to examine the effects of Sho-saiko-to.

収録刊行物

  • Jpn.J.Pharmacol.

    Jpn.J.Pharmacol. 80 (4), 379-382, 1999

    公益社団法人 日本薬理学会

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