Effects of Tri-, Di- and Monobutyltin on Synaptic Parameters of the Cholinergic System in the Cerebral Cortex of Mice.

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  • Kobayashi Haruo
    <I>Departments of I Veterinary Pharmacology Iwate University</I>
  • Suzuki Tadahiko
    <I>Departments of I Veterinary Pharmacology Iwate University</I>
  • Kasashima Yoshinori
    <I>Departments of I Veterinary Pharmacology Iwate University</I>
  • Motegi Akira
    <I>Departments of I Veterinary Pharmacology Iwate University</I>
  • Sato Itaru
    <I>Veterinary Public Health, Faculty of Agriculture, Iwate University</I>
  • Matsusaka Naonori
    <I>Veterinary Public Health, Faculty of Agriculture, Iwate University</I>
  • Ono Naoko
    <I>Departments of I Veterinary Pharmacology Iwate University</I>
  • Miura Akemi
    <I>Departments of I Veterinary Pharmacology Iwate University</I>
  • Saito Fumiya
    <I>Koiwai Farm Co.</I>
  • Saito Shin-ya
    <I>Departments of I Veterinary Pharmacology Iwate University</I>

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  • Effects of Tri Di and Monobutyltin on S

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Abstract

Triorganotin compounds like tributyltin have been reported to be biodegraded to diorganotin, monoorganotin and then inorganic tin in animals after they have been ingested. Effects of tributyltin, dibutyltin and monobutyltin on various cholinergic parameters that are involved in synaptic transmission in the mouse cerebral cortex were investigated in vitro. Tributyltin and dibutyltin, but not monobutyltin, inhibited the activity of choline acetyltransferase, both the high-affinity and low-affinity uptakes of choline into synaptosomes, and the binding of [3H]quinuclidinyl benzilate to muscarinic acetylcholine receptors. Tributyltin and dibutyltin, but not monobutyltin, had a slightly suppressive effect on the K+-induced release and synthesis of acetylcholine in slices of the cortex. A11 three butyltins at concentrations from 10−6 to 10&, inus;4M had no effect on the activity of acetylcholinesterase. The extent of the inhibitory effects on the cholinergic parameters, apart from the activity of acetylcholinesterase, was slightly greater in the case of tributyltin than dibutyltin, in particularly at the highest concentration (10−4M) tested. Therefore, it is concluded that tributyltin metabolites inhibit various parameters of cholinergic activity with a potency ranking of tributyltin > dibutyltin > monobutyltin.

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