The Effect of Acute Cold Exposure and Norepinephrine on Uncoupling Protein Gene Expression in Brown Adipose Tissue of Monosodium Glutamate-Obese Mice.

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  • Tsukahara Fujiko
    Department of Pharmacology, Tokyo Women’s Medical University, School of Medicine
  • Uchida Yoko
    Department of Pharmacology, Tokyo Women’s Medical University, School of Medicine
  • Ohba Ken-ichi
    Department of Pharmacology, Tokyo Women’s Medical University, School of Medicine
  • Ogawa Akira
    Department of Pharmacology, Tokyo Women’s Medical University, School of Medicine
  • Yoshioka Toshimasa
    Department of Pharmacology, Tokyo Women’s Medical University, School of Medicine
  • Muraki Takamura
    Department of Pharmacology, Tokyo Women’s Medical University, School of Medicine

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  • Effect of Acute Cold Exposure and Norep

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Abstract

Abnormal regulation of mitochondrial uncoupling protein (UCP) gene expression was studied in brown adipose tissue (BAT) of monosodium glutamate (MSG)-induced obese mice. UCP mRNA levels in control mice increased markedly after acute cold exposure; however, MSG-obese mice showed an impaired response. In contrast, an injection of norepinephrine (NE) induced a comparable increase in UCP mRNA levels in control and MSG-obese mice. These results suggest that the impairment in the cold-induced increase in UCP mRNA is due to a deficient sympathetic input to BAT and/or to a diminished response of BAT to endogenous NE, which constitutes the mechanism of impaired thermoregulation in obese mice in a cold environment.

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