Gastric Acid Secretion by Central Injection of Dynorphin A-(1-17), an Endogenous Ligand of κ-Opioid Receptor, in Urethane-Anesthetized Rats

DOI Web Site Web Site Web Site PubMed 参考文献67件
  • Ishihara Satomi
    Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, Chiba University
  • Tsuchiya Shizuko
    Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, Chiba University
  • Horie Syunji
    Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, Chiba University
  • Murayama Toshihiko
    Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, Chiba University
  • Watanabe Kazuo
    Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, Chiba University

書誌事項

タイトル別名
  • Gastric Acid Secretion by Central Injection of Dynorphin A-(1-17), an Endogenous Ligand of .KAPPA.-Opioid Receptor, in Urethane-Anesthetized Rats.
  • Gastric Acid Secretion by Central Injection of Dynorphin A 1 17 an Endogenous Ligand of カッパ Opioid Receptor in Urethane Anesthetized Rats

この論文をさがす

抄録

Gastric acid secretion has been proposed to be regulated by opioid receptors in the central nervous system (CNS). Previously, we reported that central injection of synthetic agonists of κ-opioid receptors stimulated gastric acid secretion in rats, and the secretion by the agonists was inhibited by norbinaltorphimine (an antagonist of κ-opioid receptor). In the present study, we investigated the effect of dynorphin A-(1 – 17), an endogenous ligand of κ-opioid receptor on the gastric acid secretion in the perfused stomach of urethane-anesthetized rats. Injection of dynorphin A-(1 – 17) (0.1 – 1 μg per rat) into the lateral cerebroventricle (LV) stimulated the secretion in a dose-dependent manner. The effect of dynorphin A-(1 – 17) was almost completely inhibited by the LV injection of norbinaltorphimine (10 μg) and in vagotomized rats. Although some studies of dynorphin A-(1 – 17) after central injection showed non-opioid effects such as the involvement of N-methyl-<sc>D</sc>-aspartate (NMDA) receptor, the effect of dynorphin A-(1 – 17) was not inhibited by a selective antagonist of the NMDA receptor ((±)-3-(2-carboxypiperazin-4-yl)-1-propylphosphonic acid, 10 μg). The LV injection of naloxone benzoylhydrazone (a κ3-opioid receptor agonist, 100 μg) also stimulated the secretion in norbinaltorphimine-sensitive manner. These findings showed that both an endogenous ligand dynorphin A-(1 – 17) and a synthetic κ3-opioid receptor agonist stimulated gastric acid secretion via κ-opioid receptors in the CNS of rats in vivo.

収録刊行物

  • Jpn.J.Pharmacol.

    Jpn.J.Pharmacol. 87 (1), 14-20, 2001

    公益社団法人 日本薬理学会

参考文献 (67)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ