Gastric Acid Secretion by Central Injection of Dynorphin A-(1-17), an Endogenous Ligand of κ-Opioid Receptor, in Urethane-Anesthetized Rats

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  • Ishihara Satomi
    Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, Chiba University
  • Tsuchiya Shizuko
    Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, Chiba University
  • Horie Syunji
    Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, Chiba University
  • Murayama Toshihiko
    Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, Chiba University
  • Watanabe Kazuo
    Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, Chiba University

書誌事項

タイトル別名
  • Gastric Acid Secretion by Central Injection of Dynorphin A-(1-17), an Endogenous Ligand of .KAPPA.-Opioid Receptor, in Urethane-Anesthetized Rats.
  • Gastric Acid Secretion by Central Injection of Dynorphin A 1 17 an Endogenous Ligand of カッパ Opioid Receptor in Urethane Anesthetized Rats

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説明

Gastric acid secretion has been proposed to be regulated by opioid receptors in the central nervous system (CNS). Previously, we reported that central injection of synthetic agonists of κ-opioid receptors stimulated gastric acid secretion in rats, and the secretion by the agonists was inhibited by norbinaltorphimine (an antagonist of κ-opioid receptor). In the present study, we investigated the effect of dynorphin A-(1 – 17), an endogenous ligand of κ-opioid receptor on the gastric acid secretion in the perfused stomach of urethane-anesthetized rats. Injection of dynorphin A-(1 – 17) (0.1 – 1 μg per rat) into the lateral cerebroventricle (LV) stimulated the secretion in a dose-dependent manner. The effect of dynorphin A-(1 – 17) was almost completely inhibited by the LV injection of norbinaltorphimine (10 μg) and in vagotomized rats. Although some studies of dynorphin A-(1 – 17) after central injection showed non-opioid effects such as the involvement of N-methyl-<sc>D</sc>-aspartate (NMDA) receptor, the effect of dynorphin A-(1 – 17) was not inhibited by a selective antagonist of the NMDA receptor ((±)-3-(2-carboxypiperazin-4-yl)-1-propylphosphonic acid, 10 μg). The LV injection of naloxone benzoylhydrazone (a κ3-opioid receptor agonist, 100 μg) also stimulated the secretion in norbinaltorphimine-sensitive manner. These findings showed that both an endogenous ligand dynorphin A-(1 – 17) and a synthetic κ3-opioid receptor agonist stimulated gastric acid secretion via κ-opioid receptors in the CNS of rats in vivo.

収録刊行物

  • Jpn.J.Pharmacol.

    Jpn.J.Pharmacol. 87 (1), 14-20, 2001

    公益社団法人 日本薬理学会

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