Activation of Background Membrane Conductance by the Tyrosine Kinase Inhibitor Tyrphostin A23 and Its Inactive Analog Tyrphostin A1 in Guinea Pig Ventricular Myocytes.
-
- Ogura Toshitsugu
- Second Department of Physiology, Kanazawa Medical University
-
- Imanishi Sunao
- Second Department of Physiology, Kanazawa Medical University
-
- Shibamoto Toshishige
- Second Department of Physiology, Kanazawa Medical University
Search this article
Abstract
The effects of the tyrosine kinase (TK) inhibitor tyrphostin A23 and its inactive analog tyrphostin A1 on background membrane conductance were investigated in guinea pig ventricular myocytes. TK-inhibiting A23 reversibly increased membrane conductance under conditions designed to minimize Na+, Ca2+, K+, and Na+-K+ pump currents. Similar stimulatory action was obtained with TK-inactive A1. The tyrphostin-induced current was inhibited by omitting external Na+ or Ca2+, suppressed by chelating internal Ca2+, blocked by external Cd2+ and Ni2+, and insensitive to changes in internal Cl− concentration. We conclude that tyrphostins have a direct, TK-independent action that increases membrane conductance probably by stimulating Na+-Ca 2+ exchange.
Journal
-
- The Japanese Journal of Pharmacology
-
The Japanese Journal of Pharmacology 87 (3), 235-239, 2001
The Japanese Pharmacological Society
- Tweet
Details 詳細情報について
-
- CRID
- 1390001204285376384
-
- NII Article ID
- 10007368537
-
- NII Book ID
- AA00691188
-
- COI
- 1:CAS:528:DC%2BD3MXovVylsbs%3D
-
- ISSN
- 13473506
- 00215198
-
- NDL BIB ID
- 5984908
-
- PubMed
- 11885974
-
- Text Lang
- en
-
- Data Source
-
- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
-
- Abstract License Flag
- Disallowed