Increase of Cl- Secretion Induced by Kampo Medicine (Japanese Herbal Medicine), Sai-rei-to, in Mongolian Gerbil Middle Ear Epithelium.

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  • Ikeda Katsuhisa
    Departments of Otorhinolaryngology, Tohoku University School of Medicine
  • Furukawa Masayuki
    Departments of Otorhinolaryngology, Tohoku University School of Medicine
  • Tanno Noriko
    Departments of Otorhinolaryngology, Tohoku University School of Medicine
  • Yamaya Mutsuo
    Departments of Geriatric Medicine, Tohoku University School of Medicine
  • Takasaka Tomonori
    Departments of Otorhinolaryngology, Tohoku University School of Medicine

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タイトル別名
  • Increase of Cl- Secretion Induced by Ka

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説明

Sai-rei-to, a type of Kampo medicine (Japanese herbal medicine), has been shown to be clinically effective in treating patients with otitis media with effusion. The effect of Sai-rei-to on the ion transport of the middle ear surface epithelium cultured from the Mongolian gerbil was investigated by using an Ussing chamber. Application of Sai-rei-to to the mucosal bath but not the serosal bath induced an increase in the short-circuit current (Isc)in the basal state. The increase in Isc was almost completely inhibited by addition of diphenylamine-2-carboxylic acid but not by amiloride, indicating enhancement of Cl- secretion. On the basis of the lack of changes in the intracellular Ca2+ concentration and a sideness of action, the effect of Sai-rei-to on Isc is thought to be a direct and selective activation on the apical Cl- channel.

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  • Jpn.J.Pharmacol.

    Jpn.J.Pharmacol. 73 (1), 29-32, 1997

    公益社団法人 日本薬理学会

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