Peroxynitrite-Generating Species. Good Candidate Oxidants in Aqueous Extracts of Cigarette Smoke.

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  • Yamaguchi Yu
    Department of Pharmacology,Faculty of Pharmaceutical Sciences,Mukogawa Women’s University,11-68,Koshien Kyuban-cho,Nishinomiya 663-8179,Japan
  • Kagota Satomi
    Department of Pharmacology,Faculty of Pharmaceutical Sciences,Mukogawa Women’s University,11-68,Koshien Kyuban-cho,Nishinomiya 663-8179,Japan
  • Haginaka Jun
    Department of Analytical Chemistry,Faculty of Pharmaceutical Sciences,Mukogawa Women’s University,11-68,Koshien Kyuban-cho,Nishinomiya 663-8179,Japan
  • Kunitomo Masaru
    Department of Pharmacology,Faculty of Pharmaceutical Sciences,Mukogawa Women’s University,11-68,Koshien Kyuban-cho,Nishinomiya 663-8179,Japan

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抄録

Cigarette smoking is a well−known risk factor for atherosclerosis, but the mechanism of the adverse biological effect of smoking remains to be established.Cigarette smoke contains high concentrations of free radicals and oxidants.We show here that cigarette smoke extracts(CSE), prepared by bubbling the gas phase of smoke into phosphate−buffered saline, could convert tyrosine to 3−nitrotyrosine.The tyrosine nitration terminated 6 h after incubating tyrosine with CSE at 37°C.These results indicate that the active oxidants in CSE are peroxynitrite−generating species like 3−morpholinosydnonimine(SIN−1), suggesting that they modify plasma lipoproteins and contribute to the pathogenesis of atherosclerosis.

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  • Jpn.J.Pharmacol.

    Jpn.J.Pharmacol. 82 (1), 78-81, 2000

    公益社団法人 日本薬理学会

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