Characterization of the Ca〔2+〕 Response Mediated by Activation of β-Adrenoceptors in Rat Submandibular Ducts
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- Nezu Akihiro
- Department of Dental Pharmacology,School of Dentistry,Health Sciences University of Hokkaido,Ishikari--Tobetsu,Hokkaido 061-0293,Japan
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- Tanimura Akihiko
- Department of Dental Pharmacology,School of Dentistry,Health Sciences University of Hokkaido,Ishikari--Tobetsu,Hokkaido 061-0293,Japan
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- Tojyo Yosuke
- Department of Dental Pharmacology,School of Dentistry,Health Sciences University of Hokkaido,Ishikari--Tobetsu,Hokkaido 061-0293,Japan
書誌事項
- タイトル別名
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- Characterization of the Ca2+ Response Mediated by Activation of .BETA.-Adrenoceptors in Rat Submandibular Ducts.
- Characterization of the Ca 2 Response Mediated by Activation of ベータ Adrenoceptors in Rat Submandibular Ducts
- Characterization of the Ca2+ Response Mediated by Activation of β-Adrenoceptors in Rat Submandibular Ducts
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The Ca2+ signaling mediated by activation of β−adrenoceptors was studied in a purified preparation of ducts from rat submandibular glands.At concentrations above 1 nM, isoproterenol(ISO)caused a small but significant increase in cytosolic Ca2+ concentration([Ca2+]i).The ISO−induced increase in [Ca2+]i was completely inhibited by the β−adrenoceptor antagonist propranolol but not by the α−adrenoceptor antagonist phentolamine.Forskolin was able to mimic the Ca2+ response to ISO.These results suggest that the ISO−induced increase in [Ca2+]i in rat submandibular ducts is mediated by an accumulation of cAMP resulting from activation of β−adrenoceptors.In the absence of extracellular Ca2+, ISO or forskolin caused a transient increase in [Ca2+]i, indicating Ca2+ mobilization from intracellular Ca2+ stores.Further, stimulation with ISO failed to mobilize Ca2+ after the depletion of intracellular Ca2+ stores by phenylephrine or carbachol, suggesting that the cAMP−mediated increase in [Ca2+]i is due to a Ca2+ release from inositol trisphosphate(IP3)−sensitive Ca2+ stores.As ISO did not stimulate a detectable production of IP3, the cAMP−mediated Ca2+ mobilization may be evoked by a mechanism different from activation of phosphoinositide hydrolysis.
収録刊行物
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- Jpn.J.Pharmacol.
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Jpn.J.Pharmacol. 84 (1), 25-31, 2000
公益社団法人 日本薬理学会
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詳細情報 詳細情報について
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- CRID
- 1390001204285476224
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- NII論文ID
- 130000077851
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- NII書誌ID
- AA00691188
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- COI
- 1:CAS:528:DC%2BD3cXmvVyrurs%3D
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- ISSN
- 13473506
- 00215198
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- NDL書誌ID
- 5526015
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- PubMed
- 11043449
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- Web Site
- http://id.ndl.go.jp/bib/5526015
- https://ndlsearch.ndl.go.jp/books/R000000004-I5526015
- https://api.elsevier.com/content/article/PII:S002151981930544X?httpAccept=text/xml
- https://api.elsevier.com/content/article/PII:S002151981930544X?httpAccept=text/plain
- https://www.jstage.jst.go.jp/article/jjp/84/1/84_1_25/_pdf
- https://search.jamas.or.jp/link/ui/2001023553
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
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