Itch-Associated Response and Antinociception Induced by Intracisternal Endomorphins in Mice.

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  • Yamaguchi Tomomi
    Department of Applied Pharmacology, Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University
  • Kitagawa Kouki
    Department of Bioorganic and Medicinal Chemistry, Niigata College of Pharmacy
  • Kuraishi Yasushi
    Department of Applied Pharmacology, Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University

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タイトル別名
  • Itch-Associated Response and Antinocice

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説明

Endomorphin-1 and endomorphin-2 are newly identified endogenous peptides and have high affinity and selectivity for μ-opioid receptors. The present experiments were conducted to determine whether intracisternal injection of these peptides would produce an itch-associated response and antinociception and to compare their effects to that of morphine. Endomorphin-1 and endomorphin-2 (0.3 - 3 nmol/mouse) elicited facial scratching characterized by bell-shaped dose-response curves with a peak effect at endomorphin-1 at 0.3 nmol/mouse and endomorphin-2 at 1 nmol/mouse. Their peak effects were inhibited by subcutaneous pretreatment with naloxone (1 mg/kg). Morphine (0.3 - 30 nmol/mouse) produced facial scratching, and its dose-response curve was also bell-shaped. Scratching of the body trunk, head and ears were not elicited by these doses of endomorphins and morphine. Endomorphin-1 and -2 at doses of 0.3 - 3 nmol/mouse produced dose-dependent antinociception, as measured with the tail-pressure test. The potency and duration of actions of these peptides were comparable to those of morphine. The results suggest that endomorphin-1 and endomorphin-2 are involved in itch-signaling and pain-inhibiting functions of the brain.

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  • Jpn.J.Pharmacol.

    Jpn.J.Pharmacol. 78 (3), 337-343, 1998

    公益社団法人 日本薬理学会

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