Serotonin-Independent Model of Cisplatin-Induced Emesis in the Ferret
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- Rudd John A.
- Department of Pharmacology, Faculty of Medicine, The Chinese University of Hong Kong
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- Cheng Celine H.K.
- Postgraduate Studies in Pharmacology, The School of Pharmacy, University of Bradford
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- Naylor Robert J.
- Postgraduate Studies in Pharmacology, The School of Pharmacy, University of Bradford
Bibliographic Information
- Other Title
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- Serotonin-Independent Model of Cisplati
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Abstract
para-Chlorophenylalanine (PCPA, 100 - 200 mg/kg) was used as a pharmacological tool to characterize the 5-hydroxytryptamine (5-HT) involvement in the emesis occurring 24 hr after the administration of cisplatin (10 mg/kg) in the ferret. PCPA was effective to antagonize the initial 8 hr period of retching and vomiting, but potentiated the emesis that occurred during the remaining 8- to 24-hr observation period. Tissue samples removed from the brainstem at 24 hr post injection of cisplatin alone revealed an elevation of 5-HT, dopamine and homovanillic acid that was antagonized by the injection of PCPA. Cisplatin also induced increases in the urinary levels of 5-hydroxyindoleacetic acid that was similarly antagonized by PCPA. Results are discussed in terms of the relevance of 5-HT to the model of cisplatin (10 mg/kg)-induced emesis in the ferret compared to the problem of acute and delayed emesis in man. The residual or delayed phase of cisplatin-induced emesis may involve a 5-HT-independent mechanism.
Journal
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- The Japanese Journal of Pharmacology
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The Japanese Journal of Pharmacology 78 (3), 253-260, 1998
The Japanese Pharmacological Society
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Details 詳細情報について
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- CRID
- 1390001204286051328
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- NII Article ID
- 10008680995
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- NII Book ID
- AA00691188
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- COI
- 1:CAS:528:DyaK1cXnslykt7Y%3D
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- ISSN
- 13473506
- 00215198
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- NDL BIB ID
- 4610813
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- PubMed
- 9869258
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- Web Site
- http://id.ndl.go.jp/bib/4610813
- https://ndlsearch.ndl.go.jp/books/R000000004-I4610813
- https://api.elsevier.com/content/article/PII:S0021519819310236?httpAccept=text/xml
- https://api.elsevier.com/content/article/PII:S0021519819310236?httpAccept=text/plain
- https://www.jstage.jst.go.jp/article/jjp/78/3/78_3_253/_pdf
- https://search.jamas.or.jp/link/ui/1999091143
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed