A Comparative Study on the Effects of Nicotine and GTS-21, a New Nicotinic Agonist, on the Locomotor Activity and Brain Monoamine Level.

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  • Nanri Masato
    Department of Pharmacology, Taiho Pharmaceutical Co., Ltd. Department of Pharmacology, Research Institute for Wakan-Yaku (Oriental Medicines), Toyama Medical and Pharmaceutical University
  • Kasahara Nobuo
    Department of Pharmacology, Taiho Pharmaceutical Co., Ltd.
  • Yamamoto Jyunji
    Department of Pharmacology, Taiho Pharmaceutical Co., Ltd.
  • Miyake Hidekazu
    Department of Pharmacology, Taiho Pharmaceutical Co., Ltd.
  • Watanabe Hiroshi
    Department of Pharmacology, Research Institute for Wakan-Yaku (Oriental Medicines), Toyama Medical and Pharmaceutical University

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タイトル別名
  • A Comparative Study on the Effects of N

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抄録

Effects of GTS-21 [3-(2, 4-dimethoxybenzylidene)-anabaseine dihydrochloride], a selective nicotinic agonist, on locomotor activity and dopamine turnover were examined and compared to those of nicotine to test if GTS-21 exhibits side effects similar to those of nicotine. GTS-21 had no effect on locomotor activity in mice or dopamine turnover in rats. In contrast, nicotine produced a biphasic effect on locomotor activity. It also enhanced dopamine turnover rates in the striatum and cerebral cortex, suggesting the involvement of dopaminergic systems in the nicotine-induced changes in locomotor activity. GTS-21 exhibits fewer adverse effects, suggesting that it has therapeutic potential for cognitive disorders related to central cholinergic dysfunction.

収録刊行物

  • Jpn.J.Pharmacol.

    Jpn.J.Pharmacol. 78 (3), 385-389, 1998

    公益社団法人 日本薬理学会

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