Pharmacology and Physiology of Perivascular Nerves Regulating Vascular Function
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- Kawasaki Hiromu
- Department of Clinical Pharmaceutical Science, Graduate School of Natural Science and Technology, Okayama University
書誌事項
- タイトル別名
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- Pharmacology and Physiology of Perivascular Nerves Regulating Vascular Function. Regulation of Vascular Function by Perivascular Calcitonin Gene-Related Peptide-Containing Nerves.
- Regulation of Vascular Function by Perivascular Calcitonin Gene-Related Peptide-Containing Nerves
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The rat mesenteric artery is innervated by nonadrenergic noncholinergic (NANC) vasodilator nerves in which calcitonin gene-related peptide (CGRP), a potent vasodilator peptide, acts as a vasodilator transmitter. The inhibition of CGRPergic nerve function potentiates a vasoconstrictor response mediated by the sympathetic adrenergic nerve, suggesting that CGRPergic nerves inhibit adrenergic function and play a role in the regulation of mesenteric vascular tone. In contrast, norepinephrine released from adrenergic nerves presynaptically inhibits neurotransmission of CGRPergic nerves. Thus, both nerves reciprocally control the vascular tone. Pathophysiological studies have shown that an age-related decrease in CGRPergic nerve-mediated vasodilation, neurogenic CGRP release and CGRP mRNA levels in the dorsal root ganglia are found in spontaneously hypertensive rats (SHR), indicating a reduced function of CGRPergic nerves. Long-term treatment with angiotensin converting enzyme inhibitor and angiotensin II-receptor antagonist restores the reduced function of CGRPergic nerves, suggesting the involvement of angiotensin II in the malfunction of CGRPergic nerves in SHR.
収録刊行物
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- Jpn.J.Pharmacol.
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Jpn.J.Pharmacol. 88 (1), 39-43, 2002
公益社団法人 日本薬理学会
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詳細情報 詳細情報について
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- CRID
- 1390001204286184576
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- NII論文ID
- 10007944660
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- NII書誌ID
- AA00691188
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- COI
- 1:STN:280:DC%2BD387itFKntQ%3D%3D
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- ISSN
- 13473506
- 00215198
- http://id.crossref.org/issn/00215198
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- NDL書誌ID
- 6054551
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- PubMed
- 11855676
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- Web Site
- http://id.ndl.go.jp/bib/6054551
- https://ndlsearch.ndl.go.jp/books/R000000004-I6054551
- https://api.elsevier.com/content/article/PII:S0021519819302288?httpAccept=text/xml
- https://api.elsevier.com/content/article/PII:S0021519819302288?httpAccept=text/plain
- https://search.jamas.or.jp/link/ui/2002164811
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 使用不可