The inhibitory effect of papaverine on respiration-dependent contracture of guinea pig taenia coli in high-K medium-1-The relationship between contracture and respiration

DOI Web Site Web Site Web Site PubMed 被引用文献6件 参考文献22件
  • TSUDA Shoji
    Department of Veterinary Pharmacology, Faculty of Agriculture, University of Tokyo
  • URAKAWA Norimoto
    Department of Veterinary Pharmacology, Faculty of Agriculture, University of Tokyo
  • SAITO Yukio
    Medical Laboratory of Pharmacology, Central Research Laboratories, Sankyo Co., Ltd.

書誌事項

タイトル別名
  • The inhibitory effect of papaverine on respiration-dependent contracture of guinea pig taenia coli in high-K medium. I. The relationship between contracture and respiration.
  • inhibitory effect of papaverine on resp

この論文をさがす

抄録

Papaverine (Pap) inhibited a tonic tension development in guinea pig taenia coli induced by an elevation of the potassium concentration of the medium to 40 mM (40-K). The ID50 of Pap was 4.5 × 10-6 M. Inhibition of the 40-K induced tonic tension by Pap was dependent on the calculated concentration of non-ionized form, but not the ionized form. Inhibition of the tonic tension by Pap and various metabolic inhibitors was not antagonized by raising the Ca++ concentration in the medium. Results obtained from simultaneous measurement of the 40-K induced O2 consumption and tension illustrated that the inhibition of O2 consumption rapidly induced the inhibition of the tension. Furthermore, glucose removal, amytal or Pap resulted in a progressive relationship between the inhibition of O2 consumption and the inhibition of tension. The inhibition of Pap as determined by O2 consumption was not reversed by application of 10-4 M 2, 4-dinitrophenol (DNP). These results plus graphical analysis of the mechanical response suggest that Pap may penetrate the cell membrane and inhibit mitochondrial respiration, thereby inhibiting this very respiration-dependent contracture.

収録刊行物

  • Jpn.J.Pharmacol.

    Jpn.J.Pharmacol. 27 (6), 833-843, 1977

    公益社団法人 日本薬理学会

被引用文献 (6)*注記

もっと見る

参考文献 (22)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ