The inhibitory effect of papaverine on respiration-dependent contracture of guinea pig taenia coli in high-K medium. III. The differential effect of papaverine and rotenone on DT diaphorase.
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- TSUDA Shuji
- Laboratory of Pharmacology, Toxicology Division, The Institute of Environmental Toxicology
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- URAKAWA Norimoto
- Department of Veterinary Pharmacology, Faculty of Agriculture, University of Tokyo
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- FUKAMI Jun-ichi
- Laboratory of Insect Toxicology, The Institute of Physical and Chemical Research
Bibliographic Information
- Other Title
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- The inhibitory effect of Papaverine on respiration-dependent contracture of guinea pig taenia coli in high-K medium-3-The differential effect of papaverine and rotenone on DT diaphorase
- inhibitory effect of Papaverine on resp
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Abstract
The differential effects of papaverine (Pap) and rotenone (Rot) were studied on the highly respiration-dependent contracture of guinea pig taenia coli in 40 mM potassium (40-K) medium, on isolated DT diaphorase activity and on mitochondrial respiration. The inhibition of guinea pig taenia coli to the 40-K induced tension by Rot (5 × 10-7 M) was fully reversed by the addition of a water soluble vitamin K3 (VK3) derivative or menadione sodium bisulfite (MSB). A low concentration (10-7-10-6 M) of Pap which had no effect on the 40-K induced tension inhibited the VK3 restored tension from the Rot suppression, corresponding to a Pap inhibition of the isolated DT diaphorase. Inhibition of the effective concentration of Pap to the 40-K induced tension development was never reversed by addition of VK3 or MSB. In taenia coli, both MSB and VK3 established a bypass of the Rot sensitive site on the mitochondrial respiratory chain by means of the DT diaphorase system. The difference in washoutefficacy between Pap and Rot on the inhibition of 40-K induced tension was ascribed to a difference in their mitochondrial binding properties.
Journal
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- The Japanese Journal of Pharmacology
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The Japanese Journal of Pharmacology 27 (6), 855-863, 1977
The Japanese Pharmacological Society
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Keywords
Details 詳細情報について
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- CRID
- 1390001204286335872
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- NII Article ID
- 130000839240
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- NII Book ID
- AA00691188
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- COI
- 1:CAS:528:DyaE1cXhs1eqsrg%3D
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- ISSN
- 13473506
- 00215198
- http://id.crossref.org/issn/00215198
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- NDL BIB ID
- 1916968
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- PubMed
- 609151
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed