Time-Dependent Changes in the Ischemic Forebrain Following the Microsphere-Induced Permanent Occlusion of Cerebral Arterioles in Rats.
-
- Okuyama Kayoko
- Discovery Research Laboratory, Tanabe Seiyaku Co., Ltd.
-
- Kiuchi Satoko
- Discovery Research Laboratory, Tanabe Seiyaku Co., Ltd.
-
- Okamoto Masahito
- Discovery Research Laboratory, Tanabe Seiyaku Co., Ltd.
-
- Iwasaki Hitoshi
- Discovery Research Laboratory, Tanabe Seiyaku Co., Ltd.
-
- Narita Hiroshi
- Discovery Research Laboratory, Tanabe Seiyaku Co., Ltd.
-
- Kudo Yukitsuka
- Discovery Research Laboratory, Tanabe Seiyaku Co., Ltd.
書誌事項
- タイトル別名
-
- Time-Dependent Changes in the Ischemic
この論文をさがす
抄録
To evaluate the progression of brain edema without modification by the effect of anesthetics, we examined the local and permanent ischemia model in unanesthetized rats. The forebrain embolism was induced by intra-arterial infusion of microspheres of 50-μm diameter in freely moving rats. From 2 to 48 hr following the injection, the water-, Na- and Ca-contents progressively increased while the K content decreased in the microsphere-injected hemisphere. After the 3rd day, the water- and Na-contents gradually decreased and returned to the normal level on the 14th day. In contrast, the Ca level remained elevated even on the 56th day. The animals showed signs of neurological deficits 24 hr after the injection. In histopathological examination, large infarct areas were present in the microsphere-injected hemisphere after 24 to 48 hr. One to two weeks later, the lateral ventricle was expanded. Eight weeks after the injection, the ventricle remained expanded and newly developed infarct areas were observed in a scattered pattern around the fibrotic area. The results show the close correlation between the development of edema and the increase/decrease of Na/K contents from the onset to the recovery from edema, and their changes are similar to those in human stroke. This model enables us to evaluate not only the acute ischemic insult but also the chronic changes of the forebrain following the stroke.
収録刊行物
-
- Jpn.J.Pharmacol.
-
Jpn.J.Pharmacol. 78 (1), 31-37, 1998
公益社団法人 日本薬理学会
- Tweet
詳細情報 詳細情報について
-
- CRID
- 1390001204286824064
-
- NII論文ID
- 10008193649
-
- NII書誌ID
- AA00691188
-
- COI
- 1:CAS:528:DyaK1cXmtlCktbs%3D
-
- ISSN
- 13473506
- 00215198
-
- NDL書誌ID
- 4565700
-
- PubMed
- 9804059
-
- Web Site
- http://id.ndl.go.jp/bib/4565700
- https://ndlsearch.ndl.go.jp/books/R000000004-I4565700
- https://api.elsevier.com/content/article/PII:S0021519819310650?httpAccept=text/xml
- https://api.elsevier.com/content/article/PII:S0021519819310650?httpAccept=text/plain
- https://www.jstage.jst.go.jp/article/jjp/78/1/78_1_31/_pdf
- https://search.jamas.or.jp/link/ui/1999018092
-
- 本文言語コード
- en
-
- データソース種別
-
- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
-
- 抄録ライセンスフラグ
- 使用不可