A New Model of Experimental Allergic Rhinitis Using Japanese Cedar Pollen in Guinea Pigs.
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- Nabe Takeshi
- Department of Pharmacology, Kyoto Pharmaceutical University
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- Shimizu Kaname
- Department of Pharmacology, Kyoto Pharmaceutical University
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- Mizutani Nobuaki
- Department of Pharmacology, Kyoto Pharmaceutical University
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- Saeki Yuji
- Department of Pharmacology, Kyoto Pharmaceutical University
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- Yamamura Hideki
- Department of Pharmacology, Kyoto Pharmaceutical University
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- Takenaka Hiroshi
- Department of Otorhinolaringology, Osaka Medical College
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- Kohno Shigekatsu
- Department of Pharmacology, Kyoto Pharmaceutical University
Bibliographic Information
- Other Title
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- New Model of Experimental Allergic Rhin
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Description
In the majority of the models of experimental allergic rhinitis, antigen challenge has been performed by single topical instillation or perfusion with the solution. The present study was performed to establish a good model using Japanese cedar pollen, which is able to repeatedly induce allergy restricted to the upper airway. Guinea pigs sensitized with the pollen extracts were subjected to quantitative and repeated inhaling of the pollen with a devised apparatus. Following the respective challenges, the nasal cavity was washed with a new technique: Washing with physiologic saline was performed from one nostril to the other one, the latter of which was kept under slightly reduced pressure. When the animal was subjected to cedar pollen inhalation, almost all the pollens inhaled were located in the upper airway. At the 5th inhalation, nasal cavity lavage revealed that both albumin leakage and histamine release into the nasal cavity were increased at maximum levels in 1 hr (respectively 2 mg and 3 ng/animal); and at the same time, a considerable number of leukocytes, especially eosinophils, were found migrating into the nasal cavity for at least 10 hr. The present methods can permit various analyses of allergic rhinitis and the assessment of drugs without sacrificing the animal over the long term.
Journal
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- The Japanese Journal of Pharmacology
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The Japanese Journal of Pharmacology 75 (3), 243-251, 1997
The Japanese Pharmacological Society
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Details 詳細情報について
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- CRID
- 1390001204286884480
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- NII Article ID
- 10008189958
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- NII Book ID
- AA00691188
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- COI
- 1:CAS:528:DyaK2sXnsFWmu78%3D
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- ISSN
- 13473506
- 00215198
- http://id.crossref.org/issn/00215198
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- NDL BIB ID
- 4346254
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- PubMed
- 9434255
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- Web Site
- http://id.ndl.go.jp/bib/4346254
- https://ndlsearch.ndl.go.jp/books/R000000004-I4346254
- https://api.elsevier.com/content/article/PII:S0021519819313022?httpAccept=text/xml
- https://api.elsevier.com/content/article/PII:S0021519819313022?httpAccept=text/plain
- https://search.jamas.or.jp/link/ui/1998083397
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed