Mouse Paw Edema Induced by a Novel Bradykinin Agonist and Its Inhibition by B2-Antagonists.
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- Ueno Akinori
- Department of Pharmacology, School of Pharmaceutical Sciences, Kitasato University
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- Naraba Hiroaki
- Department of Pharmacology, School of Pharmaceutical Sciences, Kitasato University
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- Oh-ishi Sachiko
- Department of Pharmacology, School of Pharmaceutical Sciences, Kitasato University
Bibliographic Information
- Other Title
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- Mouse Paw Edema Induced by a Novel Brad
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Abstract
A novel non-peptide bradykinin B2-receptor agonist, FR190997 (8-[2, 6-dichloro-3-[N-[(E)4-(N-methylcarbamoyl)cinnamidoacetyl]-N-methylamino]benzyloxy]-2-methyl-4-(2-pyridylmethoxy) quinoline), induced dose-dependent and longer-lasting swelling than bradykinin in the mouse paw. The swelling, peaking around 30 min, was suppressed dose-dependently by intraperitoneal administration of FR173657, a novel non-peptide B2-receptor antagonist. A known B2-antagonist, Hoe 140, also significantly suppressed this edema. The result indicates that the novel B2-agonist FR190997, being more stable than bradykinin, could induce plasma exudation locally in mice via the B2-receptor as a substitute for bradykinin.
Journal
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- The Japanese Journal of Pharmacology
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The Japanese Journal of Pharmacology 78 (1), 109-111, 1998
The Japanese Pharmacological Society
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Details 詳細情報について
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- CRID
- 1390001204286895232
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- NII Article ID
- 10008193914
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- NII Book ID
- AA00691188
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- COI
- 1:CAS:528:DyaK1cXmtlCkurc%3D
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- ISSN
- 13473506
- 00215198
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- NDL BIB ID
- 4565714
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- PubMed
- 9804073
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- Web Site
- http://id.ndl.go.jp/bib/4565714
- https://ndlsearch.ndl.go.jp/books/R000000004-I4565714
- https://api.elsevier.com/content/article/PII:S0021519819310790?httpAccept=text/xml
- https://api.elsevier.com/content/article/PII:S0021519819310790?httpAccept=text/plain
- https://www.jstage.jst.go.jp/article/jjp/78/1/78_1_109/_pdf
- https://search.jamas.or.jp/link/ui/1999000377
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed