Cerebroprotective Effects of a Novel Pyrazoline Derivative, MS-153, on Focal Ischemia in Rats.
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- Kawazura Hiroshi
- Institute of Biological Science, Mitsui Pharmaceuticals, Inc.
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- Takahashi Yasuhiro
- Institute of Biological Science, Mitsui Pharmaceuticals, Inc.
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- Shiga Yoshio
- Institute of Biological Science, Mitsui Pharmaceuticals, Inc.
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- Shimada Fumiki
- Institute of Biological Science, Mitsui Pharmaceuticals, Inc.
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- Ohto Norio
- Institute of Biological Science, Mitsui Pharmaceuticals, Inc.
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- Tamura Akira
- Department of Neurosurgery, Teikyo University, School of Medicine
書誌事項
- タイトル別名
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- Cerebroprotective Effects of a Novel Py
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MS-153 ((R)-(−)-5-methyl-l-nicotinoyl-2-pyrazoline)is a novel pyrazoline compound that has potent cerebroprotective effects in the rat focal cerebral ischemia model. Middle cerebral artery (MCA)occlusion in rats allows detailed assessment of both functional and morphological sequelae of brain infarct. Using this model, we evaluated the cerebroprotective effects of MS-153. Treatment with MS-153 (12.5 mg/kg, i.v. bolus followed by 6.25 mg/kg/hr or 25.0 mg/kg, i.v. bolus followed by 12.5 mg/kg/hr infusion for 7 days)significantly reduced infarct volumes and improved neurological deficits in MCA occluded rats 7 days after occlusion. Delayed treatment significantly reduced infarct volume 24 hr after MCA occlusion when MS-153 (25.0 mg/kg, i.v. bolus followed by 12.5 mg/kg/hr infusion for 21 hr)administration was started 3 hr after occlusion. Brain edema was also significantly improved when MS-153 (25.0 mg/kg, i.v. bolus followed by 12.5 mg/kg/hr infusion for 18 hr)administration was started 6 hr after occlusion.
収録刊行物
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- Jpn.J.Pharmacol.
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Jpn.J.Pharmacol. 73 (4), 317-324, 1997
公益社団法人 日本薬理学会
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詳細情報 詳細情報について
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- CRID
- 1390001204287046784
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- NII論文ID
- 10008677794
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- NII書誌ID
- AA00691188
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- COI
- 1:CAS:528:DyaK2sXivVeisLo%3D
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- ISSN
- 13473506
- 00215198
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- NDL書誌ID
- 4196928
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- PubMed
- 9165368
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
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- PubMed
- CiNii Articles
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- 使用不可