The Effect of Vasopressin V1- and V2-Receptor Antagonists on Hemodynamics in Early and Late Phase After Myocardial Infarction in Rats.

DOI Web Site Web Site Web Site Web Site ほか1件をすべて表示 一部だけ表示 被引用文献1件 参考文献24件
  • Fujita Hisayoshi
    First Department of Internal Medicine, Osaka City University Medical School
  • Yoshiyama Minoru
    First Department of Internal Medicine, Osaka City University Medical School
  • Takeuchi Kazuhide
    First Department of Internal Medicine, Osaka City University Medical School
  • Omura Takashi
    First Department of Internal Medicine, Osaka City University Medical School
  • Yamagishi Hiroyuki
    First Department of Internal Medicine, Osaka City University Medical School
  • Iwao Hiroshi
    Department of Pharmacology, Osaka City University Medical School
  • Miura Katuyuki
    Department of Pharmacology, Osaka City University Medical School
  • Yoshikawa Junichi
    First Department of Internal Medicine, Osaka City University Medical School

書誌事項

タイトル別名
  • Effect of Vasopressin V1-and V2-Recepto

この論文をさがす

抄録

This study was designed to access the effect of a nonpeptide vasopressin V1-receptor antagonist, OPC-21268, and a vasopressin V2-receptor antagonist, OPC-31260, on hemodynamics in the early phase and the late phase after myocardial infarction in rats. In the early phase, OPC-21268 (30 mg/kg/day) or OPC-31260 (30 mg/kg/day) was orally administered from day 1 to days 5 after the operation; and hemodynamics were measured at day 5, in the late phase from 10 weeks to 11 weeks and measured at the end of 11 weeks. In the early phase, OPC-21268 reduced the left ventricular end-diastolic pressure (LVEDP) concomitantly with the reduction in systemic blood pressure, but did not change LVEDP in the late phase. OPC-31260 reduced LVEDP and central venous pressure in both phases. OPC-21268 improved hemodynamics only in the early phase and OPC-31260 improved it in both phases.

収録刊行物

  • Jpn.J.Pharmacol.

    Jpn.J.Pharmacol. 78 (2), 229-232, 1998

    公益社団法人 日本薬理学会

被引用文献 (1)*注記

もっと見る

参考文献 (24)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ