Purinergic Signalling: Pathophysiological Roles
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- Abbracchio Maria P.
- Institute of Pharmacological Sciences, University of Milan
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- Burnstock Geoffrey
- Autonomic Neuroscience Institute, Royal Free Hospital School of Medicine
Bibliographic Information
- Other Title
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- Purinergic Signalling Pathophysiologica
- Purinergic signaling: pathophysiological roles
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Abstract
In this review, after a summary of the history and current status of the receptors involved in purinergic signalling, we focus on the distribution and physiological roles of purines and pyrimidines in both short-term events such as neurotransmission, exocrine and endocrine secretion and regulation of immune cell function, and long-term events such as cell growth, differentiation and proliferation in development and regeneration. Finally, the protective roles of nucleosides and nucleotides in events such as cancer, ischemia, wound healing, drug toxicity, inflammation and pain are explored and some suggestions made for future developments in this rapidly expanding field, with particular emphasis on the involvement of selective agonists and antagonists for purinergic receptor subtypes in therapeutic strategies.
Journal
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- The Japanese Journal of Pharmacology
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The Japanese Journal of Pharmacology 78 (2), 113-145, 1998
The Japanese Pharmacological Society
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Details 詳細情報について
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- CRID
- 1390001204287090176
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- NII Article ID
- 10008680336
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- NII Book ID
- AA00691188
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- COI
- 1:CAS:528:DyaK1cXmvFyqs70%3D
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- ISSN
- 13473506
- 00215198
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- NDL BIB ID
- 4591511
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- PubMed
- 9829617
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- Web Site
- http://id.ndl.go.jp/bib/4591511
- https://ndlsearch.ndl.go.jp/books/R000000004-I4591511
- https://api.elsevier.com/content/article/PII:S002151981931042X?httpAccept=text/xml
- https://api.elsevier.com/content/article/PII:S002151981931042X?httpAccept=text/plain
- https://www.jstage.jst.go.jp/article/jjp/78/2/78_2_113/_pdf
- https://search.jamas.or.jp/link/ui/1999067390
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed