Enhancement of Serotonin 2C Receptor mRNA Expression by Antidepressants Possessing the Receptor-Blocking Activity in the Rat Brain.
-
- Tohda Michihisa
- Department of Pharmacology, Research Institute for Wakan-yaku, Toyama Medical and Pharmaceutical University
-
- Watanabe Hiroshi
- Department of Pharmacology, Research Institute for Wakan-yaku, Toyama Medical and Pharmaceutical University
書誌事項
- タイトル別名
-
- Enhancement of Serotonin 2C Receptor mR
この論文をさがす
説明
The effects of repeated oral administration of antidepressants on the serotonin 2C receptor subtype (5-HT2CR) mRNA level in the rat brain were examined. Imipramine (20 mg/kg, p.o.) enhanced the hybridization signal in a time (days)-dependent manner, reaching a maximum at day 4 and maintaining a high level until day 14. Desipramine and mianserin, which have 5-HT2CR antagonistic activity, also stimulated the mRNA expression to about same extents as imipramine, but nomifensine, which has no effect on 5-HT2CR, was ineffective. These results suggest that long-term treatment with antidepressants, which act as 5-HT2CR antagonists, stimulates 5-HT2CR mRNA expression.
収録刊行物
-
- Jpn.J.Pharmacol.
-
Jpn.J.Pharmacol. 78 (4), 515-517, 1998
公益社団法人 日本薬理学会
- Tweet
詳細情報 詳細情報について
-
- CRID
- 1390001204287168128
-
- NII論文ID
- 10008682002
-
- NII書誌ID
- AA00691188
-
- COI
- 1:CAS:528:DyaK1MXhvFWltQ%3D%3D
-
- ISSN
- 13473506
- 00215198
-
- NDL書誌ID
- 4629559
-
- PubMed
- 9920211
-
- Web Site
- http://id.ndl.go.jp/bib/4629559
- https://ndlsearch.ndl.go.jp/books/R000000004-I4629559
- https://api.elsevier.com/content/article/PII:S0021519819310182?httpAccept=text/xml
- https://api.elsevier.com/content/article/PII:S0021519819310182?httpAccept=text/plain
- https://www.jstage.jst.go.jp/article/jjp/78/4/78_4_515/_pdf
- https://search.jamas.or.jp/link/ui/1999118259
-
- 本文言語コード
- en
-
- データソース種別
-
- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
-
- 抄録ライセンスフラグ
- 使用不可