Molecular Basis of Spatio-temporal Dynamics in Inositol 1,4,5-Trisphosphate-Mediated Ca2+ Signalling.

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  • Iino Masamitsu
    Department of Pharmacology,Graduate School of Medicine,The University of Tokyo;and CREST,Japan Science and Technology Corporation,Tokyo 113-0033,Japan

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  • Molecular Basis of Spatio-temporal Dynamics in Inositol 1,4,5-Trisphosphate-Mediated Ca〔2+〕Signalling

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Abstract

Inositol 1, 4, 5−trisphosphate(IP3)−mediated Ca2+ signalling regulates many important cell functions, and the spatio−temporal dynamics of the Ca2+ signalling is a crucial factor for its versatility.The molecular mechanisms that control Ca2+ signalling are now being investigated, and I here describe the subtypes of IP3 receptors that have distinct functional properties and contribute to the diversity of Ca2+ signalling patterns.I also discuss the spatio−temporal dynamics of intracellular IP3 concentration, describing recent methodological advances in monitoring intracellular IP3 concentration.These findings highlight the potential importance of the spatio−temporal information of any signalling molecule.

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