Chronotropic and inotropic effects of Kampo extracts in the canine isolated, blood-perfused heart preparations.

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Cardiac effects of drugs used for circulatory disorders in traditional Japanese medicine based on ancient Chinese medicine (Kampo Medicine): Saikoka-ryukotsu-borei-to, Oren-gedoku-to, Toki-shakuyaku-san, Shimbu-to, Moku-boi-to, Ryo-kei-jutsu-kan-to, Sha-kanzo-to, Keishi-ninjin-to, Toki-to and Ryo-kan-kyo-mi-shin-ge-nin-to were investigated using canine isolated, blood-perfused sinoatrial node and papillary muscle preparations. Single injections of small doses of Oren-gedoku-to, Moku-boi-to and Ryo-kan-kyo-mi-shin-ge-nin-to (0.1 to 3 mg) dosedependently increased the sinoatrial rate and the developed tension of papillary muscle, while other drugs showed almost no effect on these parameters. All the drugs had almost no effect on the blood flow through the nutrient arteries of each preparation. The positive chronotropic and inotropic effects induced by Oren-gedoku-to, Moku-boi-to and Ryo-kan-kyo-mi-shin-ge-nin-to did not show tachyphylaxis and were not affected after pharmacological denervation by tetrodotoxin treatment or by reserpine pretreatment, but were significantly suppressed by atenolol. These results indicate that these three drugs act as beta-adrenoceptor agonists to produce clinically useful cardiac effects.

収録刊行物

  • Jpn.J.Pharmacol.

    Jpn.J.Pharmacol. 51 (2), 239-246, 1989

    公益社団法人 日本薬理学会

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詳細情報 詳細情報について

  • CRID
    1390001204287350272
  • NII論文ID
    130000832618
  • DOI
    10.1254/jjp.51.239
  • COI
    1:STN:280:By%2BD1c%2Fkt10%3D
  • ISSN
    13473506
    00215198
    http://id.crossref.org/issn/00215198
  • PubMed
    2593381
  • Web Site
    https://search.jamas.or.jp/link/ui/1991056488
  • 本文言語コード
    en
  • データソース種別
    • JaLC
    • Crossref
    • PubMed
    • CiNii Articles
  • 抄録ライセンスフラグ
    使用不可

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