"Calcium entry blockers" as cerebral protecting agents: Comparative activity in tests of hypoxia and hyperexcitability.

DOI Web Site Web Site PubMed 被引用文献4件 参考文献21件

書誌事項

公開日
1985
資源種別
journal article
DOI
  • 10.1254/jjp.38.1
公開者
公益社団法人 日本薬理学会

この論文をさがす

説明

The group of drugs described as “Ca2+-entry blockers” is chemically and pharmacologically heterogenous. It is believed now that these drugs are useful in the treatment of ischemic disease. In an effort to define which drugs could offer the best therapeutic alternative, a comparative pharmacological study was made. Nine drugs (D-600 diltiazem, flunarizine, nicardipine, nifedipine, nimodipine, nitrendipine, verapamil, tiapamil) were tested in experimental screening models of brain hypoxia, ischemia, cellular intoxication and against bicucullineinduced seizures. Three types of activity were found. Verapamil, D-600, tiapamil and diltiazem were almost inactive, possibly due to their poor brain penetration. The dihydropyridines had a broad spectrum of activity, but considerable differences between these compounds exist. They all were active against hypoxia and less active against ischemia. Out of this subgroup, only nicardipine protected against metabolic intoxication and nifedipine and nicardipine could block seizure components at very high doses. Flunarizine was the only compound with a doserelated effect in all the tests. These results suggested that this combination of screening tests could be used to find compounds with an interesting activity in the field of cerebral protection.

収録刊行物

  • Jpn.J.Pharmacol.

    Jpn.J.Pharmacol. 38 (1), 1-7, 1985

    公益社団法人 日本薬理学会

被引用文献 (4)*注記

もっと見る

参考文献 (21)*注記

もっと見る

詳細情報 詳細情報について

問題の指摘

ページトップへ