Calphostin C, a Potent and Specific Inhibitor of Protein Kinase C, Reduces Phorbol Ester-Induced but Not Primary Ca2+-Induced Catecholamine Secretion from Digitonin-Permeabilized Bovine Adrenal Medullary Cells.
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- Isosaki Minoru
- Department of Pharmacology, Nara Medical University
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- Minami Naoki
- Department of Pharmacology, Nara Medical University
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- Nakashima Toshikatsu
- Department of Pharmacology, Nara Medical University
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説明
Calphostin C, a protein kinase C inhibitor, reduced phorbol ester-induced enhancement of catecholamine secretion but not primary Ca2+-induced secretion from digitonin-permeabilized bovine adrenal medullary cells, indicating that this compound selectively inhibited protein kinase C-dependent secretion.
収録刊行物
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- Jpn.J.Pharmacol.
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Jpn.J.Pharmacol. 64 (3), 217-219, 1994
公益社団法人 日本薬理学会