Persistence of Cyclopiazonic Acid-Induced Endothelium-Dependent Vasodilatation in Spontaneously Hypertensive and Streptozotocin-Induced Diabetic Rats.
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- Kamata Katsuo
- Department of Physiology and Morphology, Institute of Medicinal Chemistry, Hoshi University
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- Hayashi Tsuyoshi
- Department of Physiology and Morphology, Institute of Medicinal Chemistry, Hoshi University
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- Umeda Fujio
- Department of Physiology and Morphology, Institute of Medicinal Chemistry, Hoshi University
書誌事項
- タイトル別名
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- Persistence of Cyclopiazonic Acid-Induc
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We recently reported that cyclopiazonic acid (CPA)r eleases a novel endothelium-derived relaxing factor that is not prostacyclin, nitric oxide or endothelium-derived hyperpolarizing factor in rat mesenteric arterial bed. The acetylcholine-induced vasodilatation of the isolated mesenteric bed in spontaneously hypertensive rats (SHR) was not different from that in Wistar Kyoto rats (WKY), but it was significantly smaller in streptozotocin (STZ) -induced diabetic rats than in age-matched controls. The CPAinduced vasodilatation was not affected in SHR or in STZ-induced diabetic rats. These results suggest that the CPA-induced endothelium-dependent vasodilatation is resistant to the effects of diabetes.
収録刊行物
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- Jpn.J.Pharmacol.
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Jpn.J.Pharmacol. 73 (3), 247-250, 1997
公益社団法人 日本薬理学会
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詳細情報 詳細情報について
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- CRID
- 1390001204287841024
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- NII論文ID
- 10008677516
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- NII書誌ID
- AA00691188
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- COI
- 1:CAS:528:DyaK2sXitFKqtL4%3D
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- ISSN
- 13473506
- 00215198
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- NDL書誌ID
- 4196920
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- PubMed
- 9127820
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- Web Site
- http://id.ndl.go.jp/bib/4196920
- https://ndlsearch.ndl.go.jp/books/R000000004-I4196920
- https://api.elsevier.com/content/article/PII:S0021519819338272?httpAccept=text/xml
- https://api.elsevier.com/content/article/PII:S0021519819338272?httpAccept=text/plain
- https://search.jamas.or.jp/link/ui/1997151750
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
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- PubMed
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