Effect of APGW-Amide on [Ca〔2+〕]i in Rat Pheochromocytoma PC12 Cells

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  • Han Xiao Yan
    Department of Neurophysiology, Institute of Equilibrium Research, Gifu University School of Medicine, Gifu 500-8705, Japan
  • Ito Yuzuru
    Department of Biochemistry, Gifu University School of Medicine, Gifu 500-8705, Japan
  • Nozawa Yoshinori
    Department of Biochemistry, Gifu University School of Medicine, Gifu 500-8705, Japan
  • Jiang Yifa
    Virtual System Laboratory, Gifu University, Gifu 501-1193, Japan
  • Matsunami Kenichi
    Department of Neurophysiology, Institute of Equilibrium Research, Gifu University School of Medicine, Gifu 500-8705, Japan

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タイトル別名
  • Effect of APGW-Amide on [Ca2+]i in Rat Pheochromocytoma PC12 Cells.

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抄録

In order to determine whether Ala-Pro-Gly-Try-NH2 (APGW-amide) could affect mammalian excitable cells, we investigated the effect of APGW-amide in PC12 cells. APGW-amide caused a rapid [Ca2+]i elevation, which was completely prevented by elimination of extracellular Ca2+ with EGTA and inhibited by two L-type Ca2+ channel blockers. [Ca2+]i elevation was also blocked by a specific PKC inhibitor and prolonged pretreatment of cells with PMA. These results indicate that APGW-amide elevates [Ca2+]i in PC12 cells, possibly by Ca2+ influx via L-type Ca2+ channel activated by PKC.

収録刊行物

  • Jpn.J.Pharmacol.

    Jpn.J.Pharmacol. 84 (3), 355-359, 2000

    公益社団法人 日本薬理学会

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