Effects of Higenamine on Regulation of Ion Transport in Guinea Pig Distal Colon

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  • Liu Weixin
    First Department of Medicine, Hamamatsu University School of Medicine, 3600 Hanada-cho, Hamamatsu, 431-3192, Japan
  • Sato Yoshihiko
    First Department of Medicine, Hamamatsu University School of Medicine, 3600 Hanada-cho, Hamamatsu, 431-3192, Japan
  • Hosoda Yoshisuke
    First Department of Medicine, Hamamatsu University School of Medicine, 3600 Hanada-cho, Hamamatsu, 431-3192, Japan
  • Hirasawa Koki
    First Department of Medicine, Hamamatsu University School of Medicine, 3600 Hanada-cho, Hamamatsu, 431-3192, Japan
  • Hanai Hiroyuki
    Department of Endoscopic and Photodynamic Medicine, Hamamatsu University School of Medicine, 3600 Hanada-cho, Hamamatsu, 431-3192, Japan

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タイトル別名
  • Effects of Higenamine on Regulation of lon Transport in Guinea Pig Distal Colon.

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Effects of higenamine on Na+, K+ and Cl- transport were studied on stripped guinea pig distal colonic mucosa in vitro using Ussing chambers. Addition of 10-5M higenamine induced a biphasic change in short circuit current (Isc): a transient increase followed by a long-lasting decrease that was accompanied by an increase in transepithelial conductance (Gt). The initial phase with an increase in Isc was partially inhibited by serosal bumetanide and abolished by mucosal diphenylamine-2-carboxylate, a chloride channel blocker, indicating transient induction of Cl- secretion. The second phase with a decrease in Isc was composed of two effects: the inhibition of the amiloride-sensitive electrogenic Na+ absorption and the stimulation of the bumetanide-sensitive K+ secretion. However, the initial transient increase was not observed at the lower concentration of higenamine (10-8−10-6M). All the changes in Isc and Gt induced by higenamine were suppressed by the non-selective β-adrenergic receptor antagonist propranolol and by the β2-adrenergic receptor antagonist ICI-118, 551, but not by the β1-adrenergic-receptor-selective antagonist atenolol or by the α-antagonists phentolamine, prazosin and yohimbine. These results suggest that higenamine inhibits electrogenic Na+ absorption and stimulates electrogenic K+ and Cl- secretion through β2-adrenergic receptors in guinea pig distal colon.

収録刊行物

  • Jpn.J.Pharmacol.

    Jpn.J.Pharmacol. 84 (3), 244-251, 2000

    公益社団法人 日本薬理学会

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