Biphasic Effects of D3-Receptor Agonists, 7-OH-DPAT anD PD128907, on the D1-Receptor Agonist-Induced Hyperactivity in Mice.
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- Mori Tomohisa
- Drug Discovery, Pharmaceutical Research Center, Meiji Seika Kaisha, Ltd., 760 Morooka-cho, Kohoku-ku, Yokohama 222, Japan
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- Murase Kenshi
- Drug Discovery, Pharmaceutical Research Center, Meiji Seika Kaisha, Ltd., 760 Morooka-cho, Kohoku-ku, Yokohama 222, Japan
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- Tanaka Jiro
- Drug Discovery, Pharmaceutical Research Center, Meiji Seika Kaisha, Ltd., 760 Morooka-cho, Kohoku-ku, Yokohama 222, Japan
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- Ichimaru Yasuyuki
- Drug Discovery, Pharmaceutical Research Center, Meiji Seika Kaisha, Ltd., 760 Morooka-cho, Kohoku-ku, Yokohama 222, Japan
書誌事項
- タイトル別名
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- Biphasic Effects of D3 Receptor Agonist
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Effects of D3-receptor agonists, 7-OH-DPAT and PD128907, on the D1-receptor agonist SKF81297-induced hyperactivity in mice were examined. 7-OH-DPAT and PD128907 significantly suppressed the SKF81297-induced hyperactivity at low doses, but significantly potentiated the hyperactivity at high doses. These D3-agonists alone had no effect on the motor activity. A κ-receptor agonist that reduces dopamine release had no effect on the SKF81297-induced hyperactivity. These results suggest that lower doses of 7-OH-DPAT and PD128907 may negatively influence the D1-receptor mediated behaviors via post synaptic D3-receptors. On the other hand, higher doses of these compounds may positively influence these behaviors via D2 or D3-receptors.
収録刊行物
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- Jpn.J.Pharmacol.
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Jpn.J.Pharmacol. 73 (3), 251-254, 1997
公益社団法人 日本薬理学会
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詳細情報 詳細情報について
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- CRID
- 1390001204287873024
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- NII論文ID
- 10008677532
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- NII書誌ID
- AA00691188
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- COI
- 1:CAS:528:DyaK2sXitFKqtL8%3D
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- ISSN
- 13473506
- 00215198
- http://id.crossref.org/issn/00215198
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- NDL書誌ID
- 4196921
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- PubMed
- 9127821
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- Web Site
- http://id.ndl.go.jp/bib/4196921
- https://ndlsearch.ndl.go.jp/books/R000000004-I4196921
- https://api.elsevier.com/content/article/PII:S0021519819338284?httpAccept=text/xml
- https://api.elsevier.com/content/article/PII:S0021519819338284?httpAccept=text/plain
- https://search.jamas.or.jp/link/ui/1997145140
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- 本文言語コード
- en
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- データソース種別
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- JaLC
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- Crossref
- PubMed
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