Effect of ID-540 on averaged photopalpebral reflex in man

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  • FUTAMI Takahiro
    Household Products Research Laboratories, Kao Soap Co., Ltd.
  • SAMATA Yoko
    Household Products Research Laboratories, Kao Soap Co., Ltd.

書誌事項

タイトル別名
  • Metabolic changes with inflammation induced by a surfactant.
  • Effect of ID-540 on averaged photopalpe
  • Metabolic changes with inflammation ind
  • EFFECTS OF ID-540 ON AVERAGED PHOTOPALPEBRAL REFLEX IN MAN

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説明

Studies were carried out to determine the relationship between metabolic and histopathological changes in the gastrocnemius muscle of rats in which an acute exudative inflammation had been induced by alkyldimethylbenzylammonium chloride (alkyl-DBAC, a cationic surfactant). Succinate respiration, Na+-K+-Mg2+ ATPasc activity and ATP, ADP and AMP levels were determined as the index of metabolic changes. Myofascial edematous swelling with the acceleration of succinate oxidation and Na+-K+-Mg2+ ATPase activity was noted at 30 minutes in the inflamed muscle. The ATP level was also transiently reduced. On the other hand, Na+-K+-Mg2+ ATPase activity and succinate oxidation were inhibited by alkyl-DBAC, at this concentration, in vitro. These results support the possibility that enhancement of energy metabolism is not directly initiated by alkyl-DBAC but may be the result of certain chemical mediators released by alkyl-DBAC. The enhancement of energy metabolism continued after 1 hour and this energy may initiate leukocyte migration as well as increase vascular permeability and edema.

収録刊行物

  • Jpn.J.Pharmacol.

    Jpn.J.Pharmacol. 27 (4), 523-529, 1977

    公益社団法人 日本薬理学会

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