CORONARY COLLATERAL VASODILATOR ACTION OF N-ETHOXYCARBONYL-3-MORPHOLINOSYDNONIMINE (SIN-10) IN HEART WITH CHRONIC CORONARY INSUFFICIENCY IN DOGS
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- HIRATA MINORU
- Biological Research Laboratories, Takeda Chemical Industries, Ltd.
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- KIKUCHI KENZO
- Biological Research Laboratories, Takeda Chemical Industries, Ltd.
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Abstract
Effects of the sydnonimine derivatives on cardiovascular system have been studied (1-5), and the results in our laboratory are summarized as follows: 1) the substitution by the group containing nitrogen with —N—N—linkage in the 3-position (SIN-series) showed vasodilator and consequently hypotensive effects resembling to those of nitrites, and 2) N-acylation of imino group of sydnonimine made the compounds stable chemically (6), which probably resulted in gradual development and prolongation of the hypotensive effects as well as in decreased toxicity (4). These findings prompted us to study the effects of the derivatives on coronary collateral circulation, because nitroglycerin, the most important antianginal agent, was reported to dilate the collateral vessels which developed as a result of chronic myocardial ischem:ia (7, 8), and because the effects of agents on the collateral circulation have received considerable attention as one of the approaches to evaluate antianginal activity in laboratory experiment (9).<BR> The present study was carried out to investigate the effects of N-ethoxycarbonyl-3-morpholinosydnonimine (SIN-10) and related compounds on the coronary collateral circulation.
Journal
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- The Japanese Journal of Pharmacology
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The Japanese Journal of Pharmacology 20 (2), 187-193, 1970
The Japanese Pharmacological Society
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Details 詳細情報について
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- CRID
- 1390001204288698880
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- NII Article ID
- 130000837359
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- NII Book ID
- AA00691188
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- COI
- 1:CAS:528:DyaE3cXks1CktbY%3D
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- ISSN
- 13473506
- 00215198
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- NDL BIB ID
- 8509510
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- PubMed
- 5311558
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- Web Site
- http://id.ndl.go.jp/bib/8509510
- https://ndlsearch.ndl.go.jp/books/R000000004-I8509510
- https://api.elsevier.com/content/article/PII:S0021519819613302?httpAccept=text/xml
- https://api.elsevier.com/content/article/PII:S0021519819613302?httpAccept=text/plain
- https://search.jamas.or.jp/link/ui/1971045362
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed