Involvement of histamine H1- and H2-receptors in induced asthmas in dogs.
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- YAMATAKE Yoshikazu
- Department of Pharmacology, Hoshi College of Pharmacy
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- SASAGAWA Sumiko
- Department of Pharmacology, Hoshi College of Pharmacy
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- YANAURA Saizo
- Department of Pharmacology, Hoshi College of Pharmacy
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- KOBAYASHI Noboru
- Department of Pediatrics, Faculty of Medicine, University of Tokyo
Bibliographic Information
- Other Title
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- Involvement of histamine H1 and H2 rece
- CARDIOTONIC ACTION OF RING A-MODIFIED CARDENOLIDES, WITH SPECIAL REFERENCE TO CLEAVAGE OF THE RING
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Abstract
Participation of histamine H1- and H2-receptors in both asthmas, i.e. experimentally induced bronchoconstriction and bronchosecretion, with ascaris suum and histamine in anesthetized dogs was investigated. Dogs given 0.2% histamine solution or ascaris antigen (3 mg protein) by inhalation showed increases in respiratory resistance (Rrs) and respiratory rate to 2.5-5.0 fold. Airway secretion volume was also significantly increased 3-4 fold. The increase in Rrs by histamine inhalation was effectively inhibited or abolished by a histamine H1-receptor antagonist, chlorpheniramine (0.3-1 mg/kg i.v.), but not by a H2-receptor antagonist, cimetidine (1-3 mg/kg i.v.). The increase in Rrs by antigen inhalation was reduced by relatively high doses of chlorpheniramine (1-3 mg/kg i.v.), and not by cimetidine. In contrast, hypersecretion of tracheobronchial fluid in both asthmas was significantly prevented by either chlorpheniramine or cimetidine. Combinations of both antagonists abolished the hypersecretion. Atropine (2 mg/kg i.v.) significantly inhibited the occurrence of responses in both asthmas. The results suggest that histamine is involved in the allergic asthma produced by ascaris suum and that histamine directly evokes airway constriction through H1-receptors and hypersecretion of tracheobronchial fluid through H1 and H2-receptors, and, in a part, indirectly activates the cholinergic pathway.
Journal
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- The Japanese Journal of Pharmacology
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The Japanese Journal of Pharmacology 27 (6), 791-797, 1977
The Japanese Pharmacological Society
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Keywords
Details 詳細情報について
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- CRID
- 1390001204289040256
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- NII Article ID
- 130000839233
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- NII Book ID
- AA00691188
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- COI
- 1:CAS:528:DyaE1cXlvVKisw%3D%3D
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- ISSN
- 13473506
- 00215198
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- NDL BIB ID
- 1916969
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- PubMed
- 24777
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed