AN ELECTROPHYSIOLOGICAL STUDY OF TRANSMISSION FROM INTRAMURAL EXCITATORY NERVES TO THE SMOOTH MUSCLE CELLS OF THE CHICKEN OESOPHAGUS

DOI Web Site PubMed
  • OHASHI Hidenori
    Department of Pharmacology, Faculty of Veterinary Medicine, Hokkaido University

この論文をさがす

抄録

A fairly large number of papers dealing with the excitatory junction potential evoked by cholinergic nerve stimulation are now available (1-5). However, information about transmission from cholinergic nerves to smooth muscle cells is much less than about transmission from adrenergic nerves. This seems to be because there is no suitable preparation like the hypogastric nerve-vas deferens of the guinea-pig. Most smooth muscle cells previously used have both excitatory and inhibitory innervation and the excitatory response evoked by transmural stimulation may be modified by the inhibitory one.<BR> The aim of the present work is to investigate transmission from cholinergic nerves to smooth muscle cells using isolated strips of smooth muscle from the longitudinal layer of the upper oesophagus as far as the crop of the chicken. It has been reported that this part of the oesophagus of the chicken receives only cholinergic excitatory innervation (6, 7). As a first step toward studying the transmission, observations were made on the membrane activity of the muscle and these also are presented in this paper.<BR> The results show that the cholinergic nerve-smooth muscle junction operates by the substantially same manner as that for the sympathetic nerve-smooth muscle junction of the guinea-pig vas deferens or other neuro-effector junctions.<BR> Preliminary accounts of some of the results have already been published (8).

収録刊行物

  • Jpn.J.Pharmacol.

    Jpn.J.Pharmacol. 21 (5), 585-596, 1971

    公益社団法人 日本薬理学会

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ