INHIBITION OF SPINAL POLYSYNAPTIC REFLEX AND AUGMENTATION OF MUSCLE CONTRACTION BY 2-ETHYL-4-ETHYLAMINO-6-METHOXY-S-TRIAZINE

DOI Web Site Web Site Web Site PubMed 参考文献6件
  • 千葉 祐広
    Biological Research Laboratories, Research and Development Division, Takeda Chemical Industries, Ltd.

この論文をさがす

抄録

Our previous observation in the cat with implanted electrodes has demonstrated that 2-ethyl-4-ethylamino-6-methoxy-s-triazine (EEM) induced a long-lasting electroence-phalographic (EEG) activation and tachypnea. While the animal was initially excited as indicated by some restlessness, salivation, defecation and occasionally vocalization, thereafter it showed depressive behaviors such as mild muscular weakness, decreased locomotor activity, decreased responsiveness to extroceptive stimuli and lying prostrate throughout the EEG activation (1). Furthermore, the sympathetic excitement induced by EEM in curarized cat persisted for a considerably long period but always outlasted its EEG change (2). In the rat, this agent produced a cataleptic sign and disrupted the conditioned avoidance behavior without failure of the escape response. Despite activating both the electrical brain activity and the autonomic nervous function in such a manner, the motor function and the conditioned behavior were moderately depressed. Our preceding papers have stressed the important roles of the brain stem for the EEG activation and that of the posterior hypothalamus for the sympathetic excitements.<BR> The present experiments were carried out to study the effect of EEM on spinal reflex and muscle contraction in an attempt to clarify the mechanism of its motor depression.

収録刊行物

  • Jpn.J.Pharmacol.

    Jpn.J.Pharmacol. 19 (3), 451-459, 1969

    公益社団法人 日本薬理学会

参考文献 (6)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ