A NEW PARASYMPATHOMIMETIC AGENT: 1-METHYL-5-CHLOROINDOLINE METHYLBROMIDE

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  • TAKAYANAGI Issei
    Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, University of Tokyo
  • IRIKURA Tsutomu
    Department of Chemical Pharmacology, Kyorin Chemical Laboratory
  • NISHINO Keigo
    Department of Chemical Pharmacology, Kyorin Chemical Laboratory
  • OHKUBO Hideo
    Department of Chemical Pharmacology, Kyorin Chemical Laboratory

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Abstract

During the investigations of the effect of indoline-derivatives on the smooth muscle have been continued, we have discovered that 1-methyl-5-chloroindoline methylbromide (hereafter referred to as S-6) well contracts the isolated ileum of guinea pig. Thus, the mode of action of S-6 on the guinea pig ileum has been investigated under various conditions. The aim of this paper is to show that S-6 contracts the isolated ileum of the guinea pig possibly by acting on acetylcholine receptor directly.

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