PHARMACOLOGICAL STUDIES ON 8-[(1, 4-BENZODIOXAN-2-YL) METHYL]-3-OXO-1-THIA-4, 8-DIAZASPIRO-[4, 5]-DECANE MALEATE

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  • Pharmacological studies on 8-〔(1,4-benzodioxan-2-yl)methyl〕-3-oxo-1-thia-4,8-diazaspiro-〔4,5〕-decane meleate
  • Pharmacological studies on 8- 1 , 4-benzodioxan-2-yl methyl -3-oxo-1-thia-4 , 8-diazaspiro- 4 , 5 -decane meleate

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Studies have been so far made on the benzodioxane derivatives as a cardiovascular drug which were reported as a peripheral vasodilator, or as a hypotensive agent by Schaper et al. (1) and Green et al. (2). 8-[(1, 4-benzodioxan-2-yl) methyl]-3-oxo-l-thia-4, 8-diazaspiro-[4, 5]-decane maleate (Y-3506) was found desirable as a peripheral vasodilator with low toxicity among the new derivatives synthesized by this laboratory. This report deals with the effects of Y-3506 on the cardiovascular system of the experimental animals in comparison with those of several known vasodilators as reference compounds.

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