Effects of excitatory transmitter candidates on frog spinal motor function.
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- KIM Kiyoe
- Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Nagoya City University
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- KUDO Yoshihisa
- Department of Pharmacology, Mitubishi-Kasei, Institute of Life Sciences
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- FUKUDA Hideomi
- Department of Toxicology and Pharmacology, Faculty of Pharmaceutical Sciences, The University of Tokyo
書誌事項
- タイトル別名
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- Effects of Excitatory Transmitter Candi
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The propriospinal motor function of the frog spinal cord was investigated pharmacologically in the isolated spinal cord-nerve-muscle preparation. In the preparation with a pair of antagonistic muscles, the tissues showed reciprocal contractions in response to the spontaneous discharges from the ventral root. M. tibialis anterior responded to the discharges from the ventral root and showed slow contractions. Contractions of the m. gastrocnemius were much less frequent but the movement was rapid and strong. The addition of acetylcholine (10-4-10-3 M) to the medium, perfusing the spinal cord, resulted in a predominant excitation of m. tibialis anterior. Carbamylcholine (10-5 M) and bethanechol (10-4 M) induced rhythmical contractions in m. tibialis anterior and depressed the movement of m. gastrocnemius. These effects were blocked by atropine (10-5 M). Serotonin (10-5 M) exerted a strong facilitatory effect on both muscles which contracted reciprocally during this treatment. L-Glutamate (10-4-10-3 M) induced a transient synchronous contraction in both muscles. By means of the sucrose-gap method, cholinomimetics and serotonin proved to have no direct effect on the motoneuron, while L-glutamate had a direct effect. Results suggest that propriospinal controlling mechanisms, regulated via serotonergic and cholinergic pathways exist and drive co-ordinate muscle movement.
収録刊行物
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- Jpn.J.Pharmacol.
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Jpn.J.Pharmacol. 29 (1), 41-48, 1979
公益社団法人 日本薬理学会
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詳細情報 詳細情報について
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- CRID
- 1390001204289873536
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- NII論文ID
- 130000839592
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- NII書誌ID
- AA00691188
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- COI
- 1:CAS:528:DyaE1MXhs1Glu7Y%3D
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- ISSN
- 13473506
- 00215198
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- NDL書誌ID
- 2079805
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- PubMed
- 459156
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可