Rhythmic contractions induced by vagotomy in the fundus of rat stomach.
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- KAMATA Katsuo
- Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, The University of Tokyo
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- WATANABE Minoru
- Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Nagoya City University
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- KASUYA Yutaka
- Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, The University of Tokyo
Bibliographic Information
- Other Title
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- Rhythmic Contractions Induced by Vagoto
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Abstract
Continuous rhythmic contractions were observed in longitudinal muscle strips of fundus obtained from the chronically vagotomized rat stomach. These vagotomy-induced rhythmic contractions (VRC) were not blocked either by tetrodotoxin (3 × 10-6 M) or atropine (3 × 10-7 M), indicating that the VRC was myogenic in origin. It was also found that the VRC had the following characteristics. 1) The VRC was blocked either by 10-5 M D600 or by Ca2+ deprivation from the medium. 2) On replacement of Na+ with sucrose or of K+ with Na+, the tone of fundus strips was concomitantly elevated with the cessation of the VRC. 3) 10-5 M ouabain blocked the VRC. 4) The VRC was blocked by cooling. 5) The VRC disappeared under anoxic conditions. Based on these results possible mechanisms of the VRC are discussed in relation to an energy dependent activity of the cell membrane.
Journal
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- The Japanese Journal of Pharmacology
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The Japanese Journal of Pharmacology 29 (1), 27-32, 1979
The Japanese Pharmacological Society
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Keywords
Details 詳細情報について
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- CRID
- 1390001204289875712
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- NII Article ID
- 130000839590
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- NII Book ID
- AA00691188
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- COI
- 1:CAS:528:DyaE1MXhs1Glu7k%3D
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- ISSN
- 13473506
- 00215198
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- NDL BIB ID
- 2079814
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- PubMed
- 459154
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed