Relaxant effect of aspirin-like drugs on isolated guinea pig tracheal chain.
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- ONO Takaharu
- Research Laboratories, Fujisawa Pharmaeutical Co., Ltd.
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- OHTSUKA Minoru
- Research Laboratories, Fujisawa Pharmaeutical Co., Ltd.
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- SAKAI Shigeru
- Research Laboratories, Fujisawa Pharmaeutical Co., Ltd.
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- OHNO Syuzo
- Research Laboratories, Fujisawa Pharmaeutical Co., Ltd.
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- KUMADA Shigenobu
- Research Laboratories, Fujisawa Pharmaeutical Co., Ltd.
Bibliographic Information
- Other Title
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- Relaxant effect of aspirin like drugs o
- STUDIES ON THE ACTION POTENTIAL ORIGINATED FROM NERVE ELEMENTS IN GUINEA PIG URETER
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Abstract
The interrelation of the inhibitory effect of aspirin-like drugs on the resting tones of tracheal chain in guinea pigs, arachidonic acid-induced contraction in rat stomach fundus strips and bradykinin-induced broncheconstriction in guinea pigs in vivo was investigated. Alt the drugs tested produced a dose-related inhibitory action on the resting tonus of the tracheal chain in comparatively low doses. Diclofenac was the most potent of all the drugs and was equal in activity to isoproterenol, followed in descending order by flufenamic acid, mefenamic acid, indomethacin, ibuprofen, phenylbutazone, oxyphenbutazone and aspirin. These aspirin-like drugs also inhibited arachidonic acid-induced contraction in rat stomach fundus strips. A highly significant correlation was observed between the potency of inhibition of the arachidonic acidinduced contraction and the relaxant effect on the tracheal chain. Moreover, the drugs antagonized bradykinin-induced bronchoconstriction in guinea pigs in vivo and the order of potency roughly paralleled that of the tracheal chain. These results suggest that the aspirin-like drugs produce a reduction in resting tones of the isolated guinea pig tracheal chain by inhibition of intramural biosynthesis of prostaglandin endoperoxides.
Journal
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- The Japanese Journal of Pharmacology
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The Japanese Journal of Pharmacology 27 (6), 889-898, 1977
The Japanese Pharmacological Society
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Keywords
Details 詳細情報について
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- CRID
- 1390001204290694912
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- NII Article ID
- 130000839243
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- NII Book ID
- AA00691188
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- COI
- 1:CAS:528:DyaE1cXotlGmtA%3D%3D
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- ISSN
- 13473506
- 00215198
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- NDL BIB ID
- 1916974
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed