SEX DIFFERENCE IN THE DEVELOPMENT OF FATTY LIVER BY OROTIC ACID

DOI Web Site Web Site Web Site PubMed 被引用文献1件 参考文献28件

書誌事項

タイトル別名
  • Sex difference in the development of fa
公開日
1975
資源種別
journal article
DOI
  • 10.1254/jjp.25.289
公開者
公益社団法人 日本薬理学会

この論文をさがす

説明

Effects of orotic acid on liver lipid accumulation and incorporation of methionine [methyl-14C] into liver phosphatidylcholine and protein, and into serum beta-lipoprotein were studied. Male and female rats of Wistar strain were fed a semisynthetic diet supplemented with 1 per cent orotic acid for 7 days. Feeding of orotic acid induced a marked fatty liver in female rats, but not in males. In female rats, radioactivity in liver phosphatidylcholine was significantly decreased by orotic acid, and that in liver protein was slightly decreased. In male rats, incorporation of methionine [methyl-14C] into liver phosphatidylcholine and protein was unchanged between the control and the rats fed orotic acid. Radioactivity in serum beta-lipoprotein was decreased to a greater extent in female rats than in males. These results suggest that sex difference in the development of fatty liver may be due to the difference in the effect of orotic acid on liver phosphatidylcholine biosynthesis.

収録刊行物

  • Jpn.J.Pharmacol.

    Jpn.J.Pharmacol. 25 (3), 289-294, 1975

    公益社団法人 日本薬理学会

被引用文献 (1)*注記

もっと見る

参考文献 (28)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ