REACTION OF ANTIARRHYTHMIC AGENTS WITH AGLYCONES AND ERYTHROPHLEUM ALKALOIDS

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  • TAKEYA Norihide
    Indiana University School of Medicine Department of Pharmacology, Hiroshima University School of Medicine
  • CHEN K.K.
    Indiana University School of Medicine Department of Pharmacology, Hiroshima University School of Medicine

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  • Relation of antiarrhythmic agents with aglycones and erythrophleum alkaloids

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Abstract

The effects of DCI or BW 62-235 on the arrhythmia caused by 3 erythro-phleum alkaloids, 6 aglycones and 2 glycosides were investigated in the cat anesthetized with sodium secobarbital.<BR>Generally speaking, these agents were ineffective against coumingine or erythro-phleine arrhythmia, although arrhythmia shortening action was observed in a few cases with cassaine.<BR>These agents were ineffective against gitaloxigenin arrhythmia, however, did show evident antiarrhythmic action against digitoxigenin or periplogenin.<BR>In the cases of arrhythmia produced by hellebrigenin, bufalin or cinobufagin these agents tend to reduce the duration of the arrhythmia.<BR>In arrhythmias elicited by glycosides, duration of thevetin arrhythmia was reduced. by DCI and BW 62-235, however, the arrhythmia of scillaren A was not clearly shortened by these agents.<BR>From these results it can be concluded that there is no relationship between the effectiveness of these antiarrhythmic agents and the chemical structures of the arrhythmia inducing drugs, although some question does remain in the case of erythro-phleum alkaloids concerning intrinsic local anesthetic action. A certain relationship between the effectiveness of these agents and arrhythmic action of these cardiotonics was observed, i.e., the antiarrhythmic agents was effective against the arrhythmia caused by the drugs which have a fleeting arrhythmic action.

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