Studies on pharmacodynamic action of N-ethylmaleimide(NEM)-1-Influence of NEM on synaptic transmission of sympathetic nerves in guinea pigs
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- YAMAMOTO Hiroyuki
- Department of Pharmacology, Wakayama Medical College
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- KITANO Takafumi
- Department of Pharmacology, Wakayama Medical College
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- NISHINO Hitoo
- Department of Pharmacology, Wakayama Medical College
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- MURANO Tadashi
- Department of Pharmacology, Wakayama Medical College
書誌事項
- タイトル別名
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- STUDIES ON PHARMACODYNAMIC ACTION OF N-ETHYLMALEIMIDE (NEM)
- 1ST REPORT : INFLUENCE OF NEM ON SYNAPTIC TRANSMISSION OF SYMPATHETIC NERVES IN GUINEA PIGS
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In isolated guinea pig atrial preparations, NEM in the concentration of 5×10-5 M to 10-4 M produced an increase in the amplitude and rate of contraction at earlier stages, resulting in inhibition of contraction accompanied by an increase in resting tension and irregularity in rate at later stages, while the diphasic actions of NEM were completely antagonized by cysteine. The initial action of NEM was blocked by propranolol, guanethidine and failed to appear in the reserpinized atria, but reappeared after incubation of atria with norepinephrine indicating that it is mediated by norepinephrine. NEM augmented the contractile response of ductus deferens to hypogastric nerve stimulation at the earlier stages, but suppressed it at later stages. The augmenting effect of NEM on the response to sympathetic nerve stimulation was dependent on calcium concentrations in suspending medium. Effects of NEM on synaptic transmission of sympathetic nerves were discussed.
収録刊行物
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- Jpn.J.Pharmacol.
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Jpn.J.Pharmacol. 23 (2), 151-160, 1973
公益社団法人 日本薬理学会
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詳細情報 詳細情報について
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- CRID
- 1390001204290866176
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- NII論文ID
- 130001942870
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- NII書誌ID
- AA00691188
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- COI
- 1:CAS:528:DyaE3sXltVSnu7s%3D
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- ISSN
- 13473506
- 00215198
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- NDL書誌ID
- 7673196
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- PubMed
- 4542617
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可