Coexistence of Low-grade Sebaceous Carcinoma and Basal Cell Carcinoma in a Nevus Sebaceus

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  • MACHIDA Mio
    Department of Dermatology, Institute of Health Biosciences, The University of Tokushima Graduate School
  • HIDA Yasutoshi
    Department of Dermatology, Institute of Health Biosciences, The University of Tokushima Graduate School
  • KUBO Yoshiaki
    Department of Dermatology, Institute of Health Biosciences, The University of Tokushima Graduate School
  • ARASE Seiji
    Department of Dermatology, Institute of Health Biosciences, The University of Tokushima Graduate School
  • ANSAI Shin-ichi
    Department of Dermatology, Nippon Medical School

Bibliographic Information

Other Title
  • 低悪性度脂腺癌および基底細胞癌を併発した脂腺母斑
  • 症例 低悪性度脂腺癌および基底細胞癌を併発した脂腺母斑
  • ショウレイ テイアクセイド シセンガン オヨビ キテイ サイボウガン オ ヘイハツ シタ シセン ボハン

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Abstract

A 60-year-old Japanese man visited our outpatient clinic complaining of a black protruding tumor on his left cheek with a 3-year history. The tumor arose in a pre-existing skin-colored plaque that had been noticed since his childhood. We suspected a basal cell carcinoma (BCC) arising in a nevus sebaceus (NS), and excised the lesion including the NS. A histopathological examination of the whole specimen demonstrated the coexistence of a low-grade sebaceous carcinoma (low-grade SC) and BCC in an NS. An NS is classified into three progression stages, and various types of epithelial tumors occur secondarily in the lesion at the third stage, especially when patients are more than 50 years old. Among those secondary malignant tumors, BCC is the most common, and SC is rather rare. We reviewed the literature and summarized 31 cases of malignant sebaceous tumors arising in an NS, focusing on clinical characteristics. Surprisingly, seven cases had other malignant tumors, most of which were BCC as in our case. Only one patient with SC in an NS died from metastasis, and another 30 cases were cured after appropriate treatments. Therefore, we suggest that SC in an NS is curable by careful extirpation, although the prognosis of common SC is rather poor. But seen on the background of this case the concept of ‘low-grade SC’ should be kept in mind.

Journal

  • Nishi Nihon Hifuka

    Nishi Nihon Hifuka 73 (2), 152-156, 2011

    Western Division of Japanese Dermatological Association

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